Trial reportPloS one2016
One-Year Mortality in Older Patients with Cancer: Development and External Validation of an MNA-Based Prognostic Score.
Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Calf Circumference and All-Cause Mortality: A Systematic Review and Meta-Analysis Based on Trend Estimation Approaches.The journal of nutrition, health & aging · 2022Pooled it
- Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis.European journal of clinical nutrition · 2020Pooled it
- Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Chemotherapy: ASCO Guideline for Geriatric Oncology.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018Guideline
- Protein intake, weight loss, dietary intervention, and worsening of quality of life in older patients during chemotherapy for cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Trial
- Effects of a physical activity programme to prevent physical performance decline in onco-geriatric patients: a randomized multicentre trial.Journal of cachexia, sarcopenia and muscle · 2019Trial
- A Phase II Trial of Older Adults With Metastatic Breast Cancer Receiving nab-Paclitaxel: Melding the Fields of Geriatrics and Oncology.Clinical breast cancer · 2019Trial
- Using the Geriatric Core Dataset (G-CODE) to predict mortality in older patients with cancer: development and external validation.British journal of cancer · 2026Article
- Early host adaptation defined by nutritional and inflammatory dynamics predicts disease progression in solid tumours.American journal of cancer research · 2026Article
- Measuring calf circumference in frail hospitalized older adults and prediction of in-hospital complications and post-discharge mortality.Frontiers in medicine · 2024Article
- Association of Body Composition and Handgrip Strength with Interleukin-6 (IL-6) and Vitamin D Level in Cancer Patients.International journal of general medicine · 2023Article
- Prediction of Nursing Home Admission Using the FRAIL-NH Scale Among Older Adults in Post-Acute Care Settings.The journal of nutrition, health & aging · 2023Observational
- Comparation of different malnutrition screening tools according to GLIM criteria in cancer outpatients.European journal of clinical nutrition · 2022Observational
- Article
- Diagnostic criteria for cancer cachexia: reduced food intake and inflammation predict weight loss and survival in an international, multi-cohort analysis.Journal of cachexia, sarcopenia and muscle · 2021Article
- Development and Validation of an Early Mortality Risk Score for Older Patients Treated with Chemotherapy for Cancer.Journal of clinical medicine · 2021Article
- A prospective nutritional assessment using Mini Nutritional Assessment-short form among patients with head and neck cancer receiving concurrent chemoradiotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Quality of life, symptoms and dietary habits in oncology outpatients with malnutrition: A cross-sectional study.Medical oncology (Northwood, London, England) · 2021Article
- Impact of the antifermentative diet during radiotherapy for prostate cancer in elderly, SÃO Paulo, Brazil.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Observational
- Article
- Arti Hurria and the progress in integrating the geriatric assessment into oncology: Young International Society of Geriatric Oncology review paper.Journal of geriatric oncology · 2020Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe MNA (Mini Nutritional Assessment) is known as a prognosis factor in older population. We analyzed the prognostic value for one-year mortality of MNA items in older patients with cancer treated with chemotherapy as the basis of a simplified prognostic score.
methodsThe prospective derivation cohort included 606 patients older than 70 years with an indication of chemotherapy for cancers. The endpoint to predict was one-year mortality. The 18 items of the Full MNA, age, gender, weight loss, cancer origin, TNM, performance status and lymphocyte count were considered to construct the prognostic model. MNA items were analyzed with a backward step-by-step multivariate logistic regression and other items were added in a forward step-by-step regression. External validation was performed on an independent cohort of 229 patients.
resultsAt one year 266 deaths had occurred. Decreased dietary intake (p = 0.0002), decreased protein-rich food intake (p = 0.025), 3 or more prescribed drugs (p = 0.023), calf circumference <31 cm (p = 0.0002), tumor origin (p<0.0001), metastatic status (p = 0.0007) and lymphocyte count <1500/mm3 (0.029) were found to be associated with 1-year mortality in the final model and were used to construct a prognostic score. The area under curve (AUC) of the score was 0.793, which was higher than the Full MNA AUC (0.706). The AUC of the score in validation cohort (229 subjects, 137 deaths) was 0.698.
conclusionKey predictors of one-year mortality included cancer cachexia clinical features, comorbidities, the origin and the advanced status of the tumor. The prognostic value of this model combining a subset of MNA items and cancer related items was better than the full MNA, thus providing a simple score to predict 1-year mortality in older patients with an indication of chemotherapy.
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