Evidence map›Paper›PMID 26859295›Full record

ArticlePloS one2016

ePIANNO: ePIgenomics ANNOtation tool.

Chia-Hsin Liu, Bing-Ching Ho, Chun-Ling Chen, Ya-Hsuan Chang, Yi-Chiung Hsu, Yu-Cheng Li, Shin-Sheng Yuan, Yi-Huan Huang, Chi-Sheng Chang, Ker-Chau Li and 1 more

Abstract read
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The gymnastics of epigenomics in rice.Plant cell reports · 2018
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chia-Hsin LiuInstitute of Statistical Science, Academia Sinica, Nangang, Taipei, Taiwan.
Bing-Ching HoDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chun-Ling ChenInstitute of Statistical Science, Academia Sinica, Nangang, Taipei, Taiwan.
Ya-Hsuan ChangInstitute of Statistical Science, Academia Sinica, Nangang, Taipei, Taiwan.
Yi-Chiung HsuInstitute of Statistical Science, Academia Sinica, Nangang, Taipei, Taiwan.
Yu-Cheng LiInstitute of Statistical Science, Academia Sinica, Nangang, Taipei, Taiwan.
Shin-Sheng YuanInstitute of Statistical Science, Academia Sinica, Nangang, Taipei, Taiwan.
Yi-Huan HuangInstitute of Statistical Science, Academia Sinica, Nangang, Taipei, Taiwan.
Chi-Sheng ChangNTU Center for Genomic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
Ker-Chau LiInstitute of Statistical Science, Academia Sinica, Nangang, Taipei, Taiwan.
Hsuan-Yu ChenInstitute of Statistical Science, Academia Sinica, Nangang, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, with the development of next generation sequencing (NGS), the combination of chromatin immunoprecipitation (ChIP) and NGS, namely ChIP-seq, has become a powerful technique to capture potential genomic binding sites of regulatory factors, histone modifications and chromatin accessible regions. For most researchers, additional information including genomic variations on the TF binding site, allele frequency of variation between different populations, variation associated disease, and other neighbour TF binding sites are essential to generate a proper hypothesis or a meaningful conclusion. Many ChIP-seq datasets had been deposited on the public domain to help researchers make new discoveries. However, researches are often intimidated by the complexity of data structure and largeness of data volume. Such information would be more useful if they could be combined or downloaded with ChIP-seq data. To meet such demands, we built a webtool: ePIgenomic ANNOtation tool (ePIANNO, http://epianno.stat.sinica.edu.tw/index.html). ePIANNO is a web server that combines SNP information of populations (1000 Genomes Project) and gene-disease association information of GWAS (NHGRI) with ChIP-seq (hmChIP, ENCODE, and ROADMAP epigenomics) data. ePIANNO has a user-friendly website interface allowing researchers to explore, navigate, and extract data quickly. We use two examples to demonstrate how users could use functions of ePIANNO webserver to explore useful information about TF related genomic variants. Users could use our query functions to search target regions, transcription factors, or annotations. ePIANNO may help users to generate hypothesis or explore potential biological functions for their studies.

Indexed as

Databases, GeneticData MiningGenomicsHigh-Throughput Nucleotide SequencingHumansInternetMolecular Sequence AnnotationNF-kappa BPolymorphism, Single NucleotideTranscription FactorsUser-Computer InterfaceNF-kappa BTranscription Factors

Identifiers

PMID26859295
PMCPMC4747527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.