Evidence map›Paper›PMID 26859074›Full record

ArticleLeukemia2016

Gaq signaling is required for the maintenance of MLL-AF9-induced acute myeloid leukemia.

J R Lynch, H Yi, D A Casolari, F Voli, E Gonzales-Aloy, T K Fung, B Liu, A Brown, T Liu, M Haber and 5 more

Abstract readLetter
PubMed Publisher
In one paragraph

Article in Leukemia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Metabolism in Hematopoiesis and Its Malignancy.Advances in experimental medicine and biology · 2023
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. G Protein-Coupled Receptor Signaling in Stem Cells and Cancer.International journal of molecular sciences · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

J R LynchCancer and Stem Cell Biology Group, Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.
H YiCancer and Stem Cell Biology Group, Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.
D A CasolariAcute Leukemia Laboratory, Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, South Australia, Australia.
F VoliCancer and Stem Cell Biology Group, Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.
E Gonzales-AloyCancer and Stem Cell Biology Group, Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.ORCID 0000-0003-4323-2904
T K FungLeukaemia and Stem Cell Biology Group, Department of Haematological Medicine, King's College London, Denmark Hill, London, UK.
B LiuKids Cancer Alliance, Translational Cancer Research Centre for Kids, Cancer Institute New South Wales, Sydney, NSW, Australia.
A BrownAcute Leukemia Laboratory, Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, South Australia, Australia.
T LiuChildren's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.
M HaberChildren's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.
M D NorrisChildren's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.
I D LewisAcute Leukemia Laboratory, Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, South Australia, Australia.
C W E SoLeukaemia and Stem Cell Biology Group, Department of Haematological Medicine, King's College London, Denmark Hill, London, UK.
R J D'AndreaAcute Leukemia Laboratory, Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, South Australia, Australia.
J Y WangCancer and Stem Cell Biology Group, Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.

Funding

Cancer Research UK 16753
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsGTP-Binding Protein alpha Subunits, Gq-G11HeterograftsHumansLeukemia, Myeloid, AcuteMiceMyeloid-Lymphoid Leukemia ProteinOncogene Proteins, FusionSignal TransductionTumor Cells, CulturedGNAQ protein, humanGTP-Binding Protein alpha Subunits, Gq-G11MLL-AF9 fusion protein, humanMyeloid-Lymphoid Leukemia ProteinOncogene Proteins, Fusion

Identifiers

PMID26859074

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.