ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2016
Blunted neural responses to reward in remitted major depression: A high-density event-related potential study.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 124 citations in OpenAlex.
- Meta-analysis of neural correlates of working memory, reward, and emotion processing in major depressive disorder using ALE.Psychological medicine · 2026Pooled it
- Behavioral and electrophysiological evidence of reward processing deficits in repetitive negative thinking: Implications for depression.Psychological medicine · 2026Trial
- Differential response of positive valence systems to psychotherapy for late-life depression: A pilot study.Journal of affective disorders · 2023Trial
- The acute effects of cannabidiol on the neural correlates of reward anticipation and feedback in healthy volunteers.Journal of psychopharmacology (Oxford, England) · 2020Trial
- Effects of the KCNQ channel opener ezogabine on functional connectivity of the ventral striatum and clinical symptoms in patients with major depressive disorder.Molecular psychiatry · 2020Trial
- Neural Responsiveness to Reward as an Index of Depressive Symptom Change Following Cognitive-Behavioral Therapy and SSRI Treatment.The Journal of clinical psychiatry · 2018Trial
- Examining the independent effects of motivational factors and withdrawal mechanisms on functional impairment.Journal of psychiatric research · 2026Article
- Fatigue Symptoms Influence Effort-Based Decision-Making in Major Depressive Disorder.Biological psychiatry global open science · 2026Article
- Probing biomarkers and clinical utility of reward learning across species using the Probabilistic Reward Task: 20 years of findings.Nature. Mental health · 2026Article
- Blunted experience of pleasure, unsystematic subjective value representation, and disrupted goal-directed behaviors: an ecological momentary assessment study across mood and psychotic disorders.Schizophrenia bulletin · 2026Article
- Reverse Translation.Perspectives on behavior science · 2026Article
- Fatigue Symptoms Influence Effort-Based Decision-Making in Major Depressive Disorder.medRxiv : the preprint server for health sciences · 2025Article
- Exploring risky decision-making dynamics during antidepressant treatment in major depressive disorder: a computational modeling approach.BMC psychiatry · 2025Article
- Anticipation of pain during operant learning increases cognitive performance and feedback-related cortical potentials.Experimental brain research · 2025Article
- Leveraging stacked classifiers for exploring the role of hedonic processing between major depressive disorder and schizophrenia.Psychological medicine · 2025Article
- Hypoactivation of the Ventromedial Frontal Cortex in Major Depressive Disorder: A Magnetoencephalography Study of the Reward Positivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Computational Phenotyping of Effort-Based Decision Making in Unmedicated Adults With Remitted Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Differences in Consummatory but Not Anticipatory Reward Processing Predict Depressive Symptoms in Young Adult Women.Psychophysiology · 2025Article
- Aperiodic spectral slope tracks the effects of brain state on saliency responses in the human auditory cortex.Scientific reports · 2024Article
- Beta activity in human anterior cingulate cortex mediates reward biases.Nature communications · 2024Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMajor depressive disorder (MDD) is a highly recurrent condition, and improving our understanding of the abnormalities that persist in remitted MDD (rMDD) may provide insight into mechanisms that contribute to relapse. MDD has been characterized by reward learning deficits linked to dysfunction in frontostriatal regions. Although initial behavioral evidence of reward learning deficits in rMDD has recently emerged, it is unclear whether these reflect impairments in neural reward processing that persist into remission.
methodsWe examined behavioral reward learning and 128-channel event-related potentials (ERP) during a well-validated probabilistic reward task in 26 rMDD individuals and 34 never-depressed controls. Temporo-spatial principal components analysis (PCA) was used to separate overlapping ERP components, and group differences in neural activity in
resultsIndividuals with rMDD displayed reduced behavioral reward learning, as well as blunted ERP amplitude to reward feedback. Importantly, the reduction in ERP amplitude occurred at a PCA factor that peaked during the time at which phasic reward feedback-related signaling - hypothesized to originate in the striatum and project to the anterior cingulate cortex (ACC) - are thought to modulate scalp-recorded activity. Consistent with this, LORETA analyses revealed reduced activity in the ACC in the rMDD group, and this blunting correlated with poorer reward learning.
conclusionThese findings suggest that the reward learning impairment observed in acute MDD persists into full remission and that these impairments may be attributable to abnormalities in the neural processes that support reward feedback monitoring, particularly within the ACC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.