Evidence map›Paper›PMID 26858894›Full record

ArticleCell medicine2015

Improvement of Infusion Process in Cell Transplantation: Effect of Shear Stress on Hepatocyte Viability Under Horizontal and Vertical Syringe Orientation.

Sandi Sufiandi, Hiromichi Obara, Shin Enosawa, Huai-Che Hsu, Naoto Matsuno, Hiroshi Mizunuma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Holistic characterization of single-hepatocyte transcriptome responses to high-fat diet.American journal of physiology. Endocrinology and metabolism · 2021
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sandi SufiandiDepartment of Mechanical Engineering, Graduate School of Science and Engineering, Tokyo Metropolitan University , Hachioji, Tokyo , Japan.
Hiromichi ObaraDepartment of Mechanical Engineering, Graduate School of Science and Engineering, Tokyo Metropolitan University, Hachioji, Tokyo, Japan; †Clinical Research Center, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.
Shin Enosawa† Clinical Research Center, National Center for Child Health and Development , Setagaya-ku, Tokyo , Japan.
Huai-Che Hsu† Clinical Research Center, National Center for Child Health and Development , Setagaya-ku, Tokyo , Japan.
Naoto MatsunoDepartment of Mechanical Engineering, Graduate School of Science and Engineering, Tokyo Metropolitan University, Hachioji, Tokyo, Japan; †Clinical Research Center, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.
Hiroshi MizunumaDepartment of Mechanical Engineering, Graduate School of Science and Engineering, Tokyo Metropolitan University , Hachioji, Tokyo , Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Improving cell viability and function are important for enhancing the clinical results of cell transplantation. The relationship between cell viability and shear stress remains unexplained, and sedimentation effects during the infusion process are important to the hepatocyte transplantation process. In the present study, the relationship between cell viability and shear stress in the presence of sedimentation effect was investigated using a microchannel simulating the cell transplantation process under several shear stress conditions. Horizontal and vertical syringe orientations were employed to investigate the sedimentation effect. The vertical syringe orientation resulted in lower viability loss than the horizontal orientation. In summary, removing a sedimentation effect is important to improving cell viability by preventing high shear stress.

Indexed as

HepatocytesRectangular microchannelShear stressSyringe orientationViability loss

Identifiers

PMID26858894
PMCPMC4733837

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.