Evidence map›Paper›PMID 26858840›Full record

ArticleBMC nutrition

Reduction of Parathyroid Hormone with Vitamin D Supplementation in Blacks: A Randomized Controlled Trial.

Paulette D Chandler, Foluso Agboola, Kimmie Ng, Jamil B Scott, Bettina F Drake, Gary G Bennett, Andrew T Chan, Bruce W Hollis, Karen M Emmons, Charles S Fuchs and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nutrition. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00585637 (Defining Optimal Doses of Vitamin D for Chemoprevention in Blacks.), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00585637 phase1completednot on this map

Defining Optimal Doses of Vitamin D for Chemoprevention in Blacks.

TypeinterventionalSponsorDana-Farber Cancer InstituteRan2007 to 2013Enrolled328ConditionsGastrointestinal Cancers, Prostate Cancer, HypertensionArmsVitamin D, Placebo
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Obesity and efficacy of vitamin DCancer causes & control : CCC · 2020
    Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 1 country.

Paulette D ChandlerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA.
Foluso AgboolaDivision of Policy Translation and Leadership Development, Harvard School of Public Health, Boston, MA.
Kimmie NgHarvard Medical School, Boston, MA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
Jamil B ScottDepartment of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI.
Bettina F DrakeDepartment of Surgery, Division of Public Health Sciences, Washington University School of Medicine, St. Louis, MO.
Gary G BennettDepartment of Psychology and Neuroscience, Duke University, Durham, NC.
Andrew T ChanHarvard Medical School, Boston, MA; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA.
Bruce W HollisDivision of Pediatrics, Medical University of South Carolina, Charleston, SC.
Karen M EmmonsHarvard Medical School, Boston, MA; Center for Community-Based Research, Dana-Farber Cancer Institute, Boston, MA.
Charles S FuchsHarvard Medical School, Boston, MA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
Edward L GiovannucciHarvard Medical School, Boston, MA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, BostoN; Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA.
Harvard University · USBoston University · USBrigham and Women's Hospital · USDana-Farber Cancer Institute · USDuke University · USMedical University of South Carolina · USMichigan State University · USWashington University in St. Louis · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
Tissue and Pathology ResourcesP50CA127003 · NCI · DANA-FARBER CANCER INST · PI SHIVDASANI, RAMESH A · 2007 to 2023
$33.2M
VITamin D and omegA-3 triaL (VITAL)U01CA138962 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., MANSON, JOANN ELISABETH · 2009 to 2014
$23.6M
The VITamin D and OmegA-3 TriaL (VITAL)R01CA138962 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., MANSON, JOANN ELISABETH · 2015 to 2019
$20.9M
Mentored Patient-Oriented Research in Digestive DiseasesK24DK098311 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHAN, ANDREW T · 2013 to 2017
$930k
Role of Vitamin D, Inflammation, and Energy Balance in Colorectal Cancer SurvivalK07CA148894 · NCI · DANA-FARBER CANCER INST · PI NG, KIMMIE · 2011 to 2015
$889k
Dissemination Research to Reduce Cancer DisparitiesK05CA124415 · NCI · DANA-FARBER CANCER INST · PI EMMONS, KAREN M. · 2007 to 2011
$810k
Community-based Obesity Prevention among BlacksK22CA126992 · NCI · DUKE UNIVERSITY · PI BENNETT, GARY G · 2007 to 2009
$529k
NCATS NIH HHS UL1 TR001102NCI NIH HHS K05 CA124415NCI NIH HHS K07 CA148894NCI NIH HHS K22 CA126992NCI NIH HHS P50 CA127003NCI NIH HHS R01 CA138962NCI NIH HHS U01 CA138962NIDDK NIH HHS K24 DK098311
6 · The paper itself

Abstract

backgroundResponse of parathyroid hormone (PTH) to vitamin D supplementation is determined by the baseline PTH level and change in vitamin D status. Conflicting reports in Blacks exist on the PTH response to vitamin D to supplementation.

methodsDuring 3 winters from 2007-2010, 328 healthy Blacks (median age, 51 years) living in Boston, MA were randomized into a 4-arm, double-blind trial for 3 months of placebo, 1000, 2000, or 4000 IU of vitamin D3. PTH was measured in 254 participants at baseline and at the end of vitamin D supplementation period.

resultsThe differences in PTH between baseline and 3 months were 3.93 pg/mL for those receiving placebo, -3.37 pg/mL for those receiving 1000 IU/d, -6.76 pg/mL for those receiving 2000 IU/d, and -8.99 pg/mL for those receiving 4000 IU/d ( -2.98 pg/mL for each additional 1000 IU/d of vitamin D3; p<0.001).

conclusionWe found a significant decrease in PTH with increasing doses of vitamin D supplementation up to intakes of 4000 IU/d in Blacks. Clinical Trials.gov: NCT00585637.

Indexed as

Blacksparathyroid hormonesupplementationvitamin D

Identifiers

PMID26858840
PMCPMC4743037
OpenAlexW2204358078

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.