ArticleBiomicrofluidics2016
Enhanced contactless dielectrophoresis enrichment and isolation platform via cell-scale microstructures.
Article in Biomicrofluidics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 54 citations in OpenAlex.
- Microfluidics-enabled proteomic profiling reveal iron-driven immune evasion by an antimicrobial-resistant pathogen.Cell reports methods · 2026Article
- Label-Free Sorting of Human Mesenchymal Stem Cells Using Insulating Dielectrophoresis.Electrophoresis · 2025Article
- Characterizing Recent PDMS Changes in Electrokinetic-Based Microfluidic Devices' Performance and Manufacturing for Cell Sorting Applications.Electrophoresis · 2025Article
- Dielectrophoretic Microfluidic Designs for Precision Cell Enrichments and Highly Viable Label-Free Bacteria Recovery from Blood.Micromachines · 2025Article
- Design of a novel integrated microfluidic chip for continuous separation of circulating tumor cells from peripheral blood cells.Scientific reports · 2022Article
- Microfluidics as efficient technology for the isolation and characterization of stem cells.EXCLI journal · 2021Review
- A Prominent Cell Manipulation Technique in BioMEMS: Dielectrophoresis.Micromachines · 2020Review
- The Effect of Optically Induced Dielectrophoresis (ODEP)-Based Cell Manipulation in a Microfluidic System on the Properties of Biological Cells.Biosensors · 2020Article
- Self-aligned microfluidic contactless dielectrophoresis device fabricated by single-layer imprinting on cyclic olefin copolymer.Analytical and bioanalytical chemistry · 2020Article
- Separation of Macrophages and Fibroblasts Using Contactless Dielectrophoresis and a Novel ImageJ Macro.Bioelectricity · 2019Article
- Integration of marker-free selection of single cells at a wireless electrode array with parallel fluidic isolation and electrical lysis.Chemical science · 2019Article
- Article
- Bridging the scales in high-throughput dielectrophoretic (bio-)particle separation in porous media.Scientific reports · 2018Article
- Magnetic Force-Based Microfluidic Techniques for Cellular and Tissue Bioengineering.Frontiers in bioengineering and biotechnology · 2018Review
- Dielectrophoresis-based microfluidic platforms for cancer diagnostics.Biomicrofluidics · 2018Review
- High-throughput separation of cells by dielectrophoresis enhanced with 3D gradient AC electric field.Biomicrofluidics · 2017Article
- Integrated dielectrophoretic and surface plasmonic platform for million-fold improvement in the detection of fluorescent events.Biomicrofluidics · 2017Article
- A feasibility study for enrichment of highly aggressive cancer subpopulations by their biophysical properties via dielectrophoresis enhanced with synergistic fluid flow.Electrophoresis · 2017Article
- Alternative cDEP Design to Facilitate Cell Isolation for Identification by Raman Spectroscopy.Sensors (Basel, Switzerland) · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We designed a new microfluidic device that uses pillars on the same order as the diameter of a cell (20 μm) to isolate and enrich rare cell samples from background. These cell-scale microstructures improve viability, trapping efficiency, and throughput while reducing pearl chaining. The area where cells trap on each pillar is small, such that only one or two cells trap while fluid flow carries away excess cells. We employed contactless dielectrophoresis in which a thin PDMS membrane separates the cell suspension from the electrodes, improving cell viability for off-chip collection and analysis. We compared viability and trapping efficiency of a highly aggressive Mouse Ovarian Surface Epithelial (MOSE) cell line in this 20 μm pillar device to measurements in an earlier device with the same layout but pillars of 100 μm diameter. We found that MOSE cells in the new device with 20 μm pillars had higher viability at 350 VRMS, 30 kHz, and 1.2 ml/h (control 77%, untrapped 71%, trapped 81%) than in the previous generation device (untrapped 47%, trapped 42%). The new device can trap up to 6 times more cells under the same conditions. Our new device can sort cells with a high flow rate of 2.2 ml/h and throughput of a few million cells per hour while maintaining a viable population of cells for off-chip analysis. By using the device to separate subpopulations of tumor cells while maintaining their viability at large sample sizes, this technology can be used in developing personalized treatments that target the most aggressive cancerous cells.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.