ArticleStem cells international2016
Cancer Stem Cell Plasticity as Tumor Growth Promoter and Catalyst of Population Collapse.
Article in Stem cells international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Review
- Transitional dynamics of cancer stem cells in invasion and metastasis.Translational oncology · 2021Review
- Integrating transcriptomics and bulk time course data into a mathematical framework to describe and predict therapeutic resistance in cancer.Physical biology · 2020Article
- Exosomal lncRNA DOCK9-AS2 derived from cancer stem cell-like cells activated Wnt/β-catenin pathway to aggravate stemness, proliferation, migration, and invasion in papillary thyroid carcinoma.Cell death & disease · 2020Article
- Article
- Modeling heterogeneous tumor growth dynamics and cell-cell interactions at single-cell and cell-population resolution.Current opinion in systems biology · 2019Article
- Exosomal FMR1-AS1 facilitates maintaining cancer stem-like cell dynamic equilibrium via TLR7/NFκB/c-Myc signaling in female esophageal carcinoma.Molecular cancer · 2019Article
- A multi-state model of chemoresistance to characterize phenotypic dynamics in breast cancer.Scientific reports · 2018Article
- Emerging role of exosome signalling in maintaining cancer stem cell dynamic equilibrium.Journal of cellular and molecular medicine · 2018Review
- Effect of cellular de-differentiation on the dynamics and evolution of tissue and tumor cells in mathematical models with feedback regulation.Journal of theoretical biology · 2018Article
- Biological noise and positional effects influence cell stemness.The Journal of biological chemistry · 2018Article
- Stem Cell Plasticity and Niche Dynamics in Cancer Progression.IEEE transactions on bio-medical engineering · 2017Article
- Agent-Based Modeling of Cancer Stem Cell Driven Solid Tumor Growth.Methods in molecular biology (Clifton, N.J.) · 2016Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is increasingly argued that cancer stem cells are not a cellular phenotype but rather a transient state that cells can acquire, either through intrinsic signaling cascades or in response to environmental cues. While cancer stem cell plasticity is generally associated with increased aggressiveness and treatment resistance, we set out to thoroughly investigate the impact of different rates of plasticity on early and late tumor growth dynamics and the response to therapy. We develop an agent-based model of cancer stem cell driven tumor growth, in which plasticity is defined as a spontaneous transition between stem and nonstem cancer cell states. Simulations of the model show that plasticity can substantially increase tumor growth rate and invasion. At high rates of plasticity, however, the cells get exhausted and the tumor will undergo spontaneous remission in the long term. In a series of in silico trials, we show that such remission can be facilitated through radiotherapy. The presented study suggests that stem cell plasticity has rather complex, nonintuitive implications on tumor growth and treatment response. Further theoretical, experimental, and integrated studies are needed to fully decipher cancer stem cell plasticity and how it can be harnessed for novel therapeutic approaches.
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Registered trials
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