Evidence map›Paper›PMID 26858660›Full record

ReviewFrontiers in psychiatry2016

Revisiting the Basic Symptom Concept: Toward Translating Risk Symptoms for Psychosis into Neurobiological Targets.

Frauke Schultze-Lutter, Martin Debbané, Anastasia Theodoridou, Stephen J Wood, Andrea Raballo, Chantal Michel, Stefanie J Schmidt, Jochen Kindler, Stephan Ruhrmann, Peter J Uhlhaas

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.

  1. Pooled it
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  3. Basic symptoms of psychosis-from historical foundations to current evidence.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 4 countries.

Frauke Schultze-LutterUniversity Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern , Bern , Switzerland.
Martin DebbanéDevelopmental Clinical Psychology Research Unit, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland; Research Department of Clinical, Educational and Health Psychology, University College London, London, UK.
Anastasia TheodoridouDepartment of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry , Zurich , Switzerland.
Stephen J WoodSchool of Psychology, University of Birmingham , Birmingham , UK.
Andrea RaballoNorwegian Centre for Mental Disorders Research (NORMENT), Faculty of Medicine, University of Oslo , Oslo , Norway.
Chantal MichelUniversity Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern , Bern , Switzerland.
Stefanie J SchmidtUniversity Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern , Bern , Switzerland.
Jochen KindlerUniversity Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern , Bern , Switzerland.
Stephan RuhrmannDepartment of Psychiatry and Psychotherapy, University of Cologne , Cologne , Germany.
Peter J UhlhaasInstitute of Neuroscience and Psychology, University of Glasgow , Glasgow , UK.
University of Bern · CHUniversity College London · GBUniversity Hospital of Zurich · CHUniversity of Birmingham · GBUniversity of Cologne · DEUniversity of Glasgow · GBUniversity of Oslo · NO

Funding

Medical Research Council MR/K013599/1Medical Research Council MR/N003403/1
6 · The paper itself

Abstract

In its initial formulation, the concept of basic symptoms (BSs) integrated findings on the early symptomatic course of schizophrenia and first in vivo evidence of accompanying brain aberrations. It argued that the subtle subclinical disturbances in mental processes described as BSs were the most direct self-experienced expression of the underlying neurobiological aberrations of the disease. Other characteristic symptoms of psychosis (e.g., delusions and hallucinations) were conceptualized as secondary phenomena, resulting from dysfunctional beliefs and suboptimal coping styles with emerging BSs and/or concomitant stressors. While BSs can occur in many mental disorders, in particular affective disorders, a subset of perceptive and cognitive BSs appear to be specific to psychosis and are currently employed in two alternative risk criteria. However, despite their clinical recognition in the early detection of psychosis, neurobiological research on the aetiopathology of psychosis with neuroimaging methods has only just begun to consider the neural correlate of BSs. This perspective paper reviews the emerging evidence of an association between BSs and aberrant brain activation, connectivity patterns, and metabolism, and outlines promising routes for the use of BSs in aetiopathological research on psychosis.

Indexed as

aetiopathologybasic symptomsclinical high riskneurobiologypsychosis

Identifiers

PMID26858660
PMCPMC4729935
OpenAlexW2265492199

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.