ReviewOncoTargets and therapy2016
Utility of blood procalcitonin concentration in the management of cancer patients with infections.
Review in OncoTargets and therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Diagnostic accuracy of procalcitonin in adult non-neutropenic cancer patients with suspected infection: a systematic review and meta-analysis.BMC infectious diseases · 2024Pooled it
- Marked Non-Infectious Elevation of Procalcitonin in a Hemodialysis Patient with Bladder Cancer: A Case Report.Infection and drug resistance · 2026Article
- Article
- Highly elevated sepsis biomarkers in advanced cholangiocarcinoma without sepsis: A case report and literature review.Medicine · 2025Review
- Bilateral breast swelling in a pregnant woman with high-grade B-cell lymphoma, potentially Burkitt lymphoma.Radiology case reports · 2025Article
- Clinical features, procalcitonin concentration, and bacterial infection in febrile hospitalized cancer patients: a descriptive study and association analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Incidental diagnosis of medullary thyroid microcarcinoma in COVID-19 patient with elevated procalcitonin levels.Archive of clinical cases · 2024Article
- Clinical course and outcomes of cancer patients admitted in medical ICU with sepsis.Journal of the Intensive Care Society · 2023Article
- Tricky sepsis biomarker: Extremely high procalcitonin in squamous cell lung cancer with doubtful infection.Respirology case reports · 2023Article
- The utility of procalcitonin for diagnosing bacteremia and bacterial pneumonia in hospitalized oncology patients.Journal of cancer research and clinical oncology · 2023Article
- Use of serum procalcitonin (PCT) level and PCT mRNA expression as a potential clinical biomarker in cats with bacterial and viral infections.Journal of feline medicine and surgery · 2022Article
- The ability of inflammatory markers to recognize infection in cancer patients with fever at admission.Immunologic research · 2022Article
- A retrospective cohort study of the effect of rapid versus delayed-result procalcitonin testing on antibiotic use at a community hospital.International journal of clinical pharmacy · 2022Article
- Predictive value of Leukocyte ImmunoTest (LIT™) in cancer patients: a prospective cohort study.Frontiers in oncology · 2022Article
- Article
- Circulating nuclear factor-kappa B mediates cancer-associated inflammation in human breast and colon cancer.Journal of medical biochemistry · 2021Article
- The role of procalcitonin and presepsin in the septic febrile neutropenia in acute leukemia patients.PloS one · 2021Article
- Procalcitonin and C-Reactive Protein/Procalcitonin Ratio as Markers of Infection in Patients With Solid Tumors.Frontiers in medicine · 2021Article
- Application of Machine Learning for the Prediction of Etiological Types of Classic Fever of Unknown Origin.Frontiers in public health · 2021Article
- Cabozantinib as the causative agent of high-grade fever in a patient with a background of metastatic clear cell renal cell carcinoma: a case report.Journal of medical case reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diagnosis of infections in cancer patients is usually problematic since differentiating between infection and fever of unknown origin is often a considerable clinical challenge. In general, increase concentration of blood procalcitonin (PCT) is associated with severe bacterial infection. PCT with an optimal cutoff level of 0.5 ng/mL seems to be the most helpful biochemical parameter in detecting severe infections, mainly bloodstream infection, in patients with hematological cancers. In all clinical situations, the elevated level of PCT should be carefully analyzed, always with a thorough physical examination and an appropriate microbiological assessment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.