ArticleProceedings of the National Academy of Sciences of the United States of America2016
Balanced feedforward inhibition and dominant recurrent inhibition in olfactory cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Adult-neurogenesis allows for representational stability and flexibility in early olfactory system.eLife · 2026Article
- A corticothalamic circuit modulates pain sensitivity and mediates innate fear-induced analgesia in male mice.Nature communications · 2026Article
- How the olfactory bulb maintains stable odor manifolds amid adaptation and representational drift.bioRxiv : the preprint server for biology · 2026Article
- Projection-specific Routing of Odor Information in the Olfactory Cortex.bioRxiv : the preprint server for biology · 2025Article
- Disinhibitory Circuitry Gates Associative Synaptic Plasticity in Olfactory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- Dopamine Increases the Intrinsic Excitability of Parvalbumin-Expressing Fast-Spiking Cells in the Piriform Cortex.Frontiers in cellular neuroscience · 2022Article
- The Anterior Piriform Cortex and Predator Odor Responses: Modulation by Inhibitory Circuits.Frontiers in behavioral neuroscience · 2022Review
- TNF-α Orchestrates Experience-Dependent Plasticity of Excitatory and Inhibitory Synapses in the Anterior Piriform Cortex.Frontiers in neuroscience · 2022Article
- Nonlinear transient amplification in recurrent neural networks with short-term plasticity.eLife · 2021Article
- Target-specific control of piriform cortical output via distinct inhibitory circuits.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Chronic loss of inhibition in piriform cortex following brief, daily optogenetic stimulation.Cell reports · 2021Article
- Odor coding in piriform cortex: mechanistic insights into distributed coding.Current opinion in neurobiology · 2020Review
- Article
- Cell-Type-Specific Whole-Brain Direct Inputs to the Anterior and Posterior Piriform Cortex.Frontiers in neural circuits · 2020Article
- Glutamatergic Neurons in the Piriform Cortex Influence the Activity of D1- and D2-Type Receptor-Expressing Olfactory Tubercle Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Peripheral Nerve Ligation Elicits Widespread Alterations in Cortical Sensory Evoked and Spontaneous Activity.Scientific reports · 2019Article
- Rapid Changes in Synaptic Strength After Mild Traumatic Brain Injury.Frontiers in cellular neuroscience · 2019Article
- Top-down inputs drive neuronal network rewiring and context-enhanced sensory processing in olfaction.PLoS computational biology · 2019Article
- Article
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4 authors.
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Abstract
Throughout the brain, the recruitment of feedforward and recurrent inhibition shapes neural responses. However, disentangling the relative contributions of these often-overlapping cortical circuits is challenging. The piriform cortex provides an ideal system to address this issue because the interneurons responsible for feedforward and recurrent inhibition are anatomically segregated in layer (L) 1 and L2/3 respectively. Here we use a combination of optical and electrical activation of interneurons to profile the inhibitory input received by three classes of principal excitatory neuron in the anterior piriform cortex. In all classes, we find that L1 interneurons provide weaker inhibition than L2/3 interneurons. Nonetheless, feedforward inhibitory strength covaries with the amount of afferent excitation received by each class of principal neuron. In contrast, intracortical stimulation of L2/3 evokes strong inhibition that dominates recurrent excitation in all classes. Finally, we find that the relative contributions of feedforward and recurrent pathways differ between principal neuron classes. Specifically, L2 neurons receive more reliable afferent drive and less overall inhibition than L3 neurons. Alternatively, L3 neurons receive substantially more intracortical inhibition. These three features--balanced afferent drive, dominant recurrent inhibition, and differential recruitment by afferent vs. intracortical circuits, dependent on cell class--suggest mechanisms for olfactory processing that may extend to other sensory cortices.
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