ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2016
Predictors of Optimal Cognitive Aging in 80+ Women: The Women's Health Initiative Memory Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Exploring the sensitivity of episodic and spatial memory tests to healthy and pathological cognitive aging.Frontiers in aging neuroscience · 2025Article
- The Paradox in Positive and Negative Aspects of Emotional Functioning Among Older Adults with Early Stages of Cognitive Impairment.Journal of aging and health · 2024Article
- Predictors of cognitive change in cognitively healthy older women in Panama: the PARI-HD study.Frontiers in global women's health · 2024Article
- High performance older adults in a population-based sample with low education: Pietà study.Arquivos de neuro-psiquiatria · 2023Article
- Age- and cognition-related differences in the gray matter volume of the chimpanzee brain (Pan troglodytes): A voxel-based morphometry and conjunction analysis.American journal of primatology · 2021Article
- Investigating Predictors of Preserved Cognitive Function in Older Women Using Machine Learning: Women's Health Initiative Memory Study.Journal of Alzheimer's disease : JAD · 2021Article
- Current State of Diabetes Mellitus Prevalence, Awareness, Treatment, and Control in Latin America: Challenges and Innovative Solutions to Improve Health Outcomes Across the Continent.Current diabetes reports · 2020Review
- Neuropsychological assessment of mild cognitive impairment in Latinx adults: A scoping review.Neuropsychology · 2020Article
- Work Hours and Cognitive Function: The Multi-Ethnic Study of Atherosclerosis.Safety and health at work · 2020Article
- Cognitive resilience among APOE ε4 carriers in the oldest old.International journal of geriatric psychiatry · 2019Article
- What are the threats to successful brain and cognitive aging?Neurobiology of aging · 2019Article
- Article
- A candidate gene study of risk for dementia in older, postmenopausal women: Results from the Women's Health Initiative Memory Study.International journal of geriatric psychiatry · 2019Article
- Association between insomnia symptoms and cognitive impairment in the Cretan Aging Cohort.European geriatric medicine · 2018Article
- "Exceptional brain aging" without Alzheimer's disease: triggers, accelerators, and the net sum game.Alzheimer's research & therapy · 2018Article
- Elevated Soluble Vascular Cell Adhesion Molecule-1 Is Associated With Cerebrovascular Resistance and Cognitive Function.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Socioeconomic, health, and psychosocial mediators of racial disparities in cognition in early, middle, and late adulthood.Psychology and aging · 2017Article
- Genetic Analysis of Mitochondrial Ribosomal Proteins and Cognitive Aging in Postmenopausal Women.Frontiers in genetics · 2017Article
- Alcohol Intake and Cognitively Healthy Longevity in Community-Dwelling Adults: The Rancho Bernardo Study.Journal of Alzheimer's disease : JAD · 2017Article
- Type 2 Diabetes, Cognition, and Dementia in Older Adults: Toward a Precision Health Approach.Diabetes spectrum : a publication of the American Diabetes Association · 2016Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundIndependent predictors of preserved cognitive functioning and factors associated with maintaining high preserved cognitive function in women ≥ 80 years remain elusive.
methodsTwo thousand two hundred twenty-eight women with a mean age of 85 years who participated in the Women's Health Initiative Memory Study were classified as cognitively normal (n = 1,905, 85.5%), mild cognitive impairment (n = 88, 3.9%), dementia (n = 121, 5.4%) or other cognitive impairment (n = 114, n = 5.1%) by central adjudication. Global cognitive functioning was assessed using telephone interview for cognitive status-modified in those women who did not meet cognitive impairment criteria. Differences between women grouped by cognitive status with respect to each potential risk factor were assessed using chi-squared tests and t-tests. Backward stepwise logistic regression was used to select factors that were independently associated with cognitive status.
resultsFactors associated with preserved cognitive functioning were younger age, higher education, and family incomes, being non-Hispanic white, better emotional wellbeing, fewer depressive symptoms, more insomnia complaints, being free of diabetes, and not carrying the apolipoprotein E-epsilon 4 allele. Cognitively normal women who demonstrated sustained high preserved cognition were younger, more educated, and endorsed better self-reported general health, emotional wellbeing, and higher physical functioning.
conclusionsAddressing sociodemographic disparities such as income inequality, and targeting interventions to improve depressive symptoms and vascular risk factors, including diabetes, may play an important role in preserving cognition among women who survive to 80 years of age. Person-centered approaches that combine interventions to improve physical, cognitive, and psychosocial functioning may promote maintenance of high preserved cognitive health in the oldest-old.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.