Evidence map›Paper›PMID 26858323›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2016

Physical Functioning Among Women Aged 80 Years and Older With Previous Fracture.

Carolyn J Crandall, Michael J LaMonte, Beverly M Snively, Meryl S LeBoff, Jane A Cauley, Cora E Lewis, Robert Wallace, Wenjun Li, Zhao Chen, John A Robbins and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Carolyn J CrandallDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles. ccrandall@mednet.ucla.edu.
Michael J LaMonteDepartment of Epidemiology and Environmental Health, University at Buffalo, the State University of New York.
Beverly M SnivelyDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Meryl S LeBoffDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Jane A CauleyDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania.
Cora E LewisDepartment of Medicine, University of Alabama, Birmingham.
Robert WallaceDepartment of Epidemiology, University of Iowa.
Wenjun LiDepartment of Medicine, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester.
Zhao ChenDivision of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson.
John A RobbinsDepartment of Medicine, Center for Healthcare Policy and Research, UC Davis Medical Center, Sacramento, California.
Jean Wactawski-WendeDepartment of Epidemiology and Environmental Health, University at Buffalo, the State University of New York.
Harvard University · USUniversity of Alabama at Birmingham · USUniversity of Arizona · USUniversity of Iowa · USUniversity of Massachusetts Chan Medical School · USUniversity of Pittsburgh · USWake Forest University · US

Funding

VITamin D and OmegA-3 TriaL (VITAL): Interrelationship of Vitamin D and Vitamin K on BoneR01AR059775 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LEBOFF, MERYL SUSAN · 2012 to 2022
$3.9M
VITamin D OmegA-3 TriaL (VITAL): Fractures, Vitamin D and Genetic MarkersR01AR070854 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LEBOFF, MERYL SUSAN · 2018 to 2022
$2.8M
NIAMS NIH HHS R01 AR059775NIAMS NIH HHS R01 AR070854PHS HHS 268201100001CPHS HHS 268201100002CPHS HHS 268201100003CPHS HHS 268201100004CPHS HHS 268201100046CPHS HHS 271201100004C
6 · The paper itself

Abstract

backgroundThe oldest old are the fastest growing segment of the elderly population. Little is known regarding the associations of fracture history with physical functioning assessed after age 80.

methodsAmong 33,386 women surviving to age 80 years (mean ± SD years 84.6 ± 3.4), we examined the relationship between history of incident fracture after entry into the Women's Health Initiative (follow-up 15.2 ± 1.3 years) and their physical functioning assessed using the RAND-36 instrument most proximal to 2012 end of follow-up.

resultsBaseline mean (±SD) physical function score was 82 (± 18). After adjustment for demographic and medical characteristics, fracture at each site, including hip, upper limb, lower limb, and central body, was associated with significantly lower subsequent physical functioning (all p < .001). Hip, upper leg, spine, and pelvis fractures were particularly related with lower physical functioning scores, 11.7 (95% CI: 10.3, 13.1), 10.5 (8.8, 12.3), 9.8 (8.9, 10.8), and 8.7 (7.2, 10.2) units lower, respectively, compared with women without fracture (each p < .0001). Compared with women without central site fracture, women with central site fractures also had lower physical functioning scores (10.0 [9.3, 10.8] units lower]; p < .0001). In case-only analysis of fractures, older age, less than 1 year since fracture, one or more additional sites fractured, history of cardiovascular disease or cancer, higher body mass index, and no alcohol intake in the past 3 months also were independent predictors of lower physical functioning score (all p < .05).

conclusionsAmong women surviving to 80 years and older, prior fracture is associated with lower current physical functioning, regardless of anatomical site of fracture, independent of other major predictors of disability.

Indexed as

Disability EvaluationGeriatric AssessmentWomen's HealthAged, 80 and overAgingFemaleFractures, BoneFrail ElderlyHealth StatusHealth SurveysHumansQuality of LifeSurvivorsUnited StatesFractureFrailtyPhysical function

Identifiers

PMID26858323
PMCPMC4861138
OpenAlexW2329688486

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.