Evidence map›Paper›PMID 26858258›Full record

ArticleJournal of feline medicine and surgery2017

Clinical, pathological, immunohistochemical and molecular characterization of feline chronic gingivostomatitis.

Veronica Machado Rolim, Saulo Petinatti Pavarini, Fabrício Souza Campos, Viviam Pignone, Cláudia Faraco, Marcelo de Souza Muccillo, Paulo Michel Roehe, Fernanda Viera Amorim da Costa, David Driemeier

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of feline medicine and surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  14. Dental Pain in Cats: A Prospective 6-Month Study.Journal of veterinary dentistry · 2022
    Review
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  16. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Veronica Machado Rolim1 Department of Veterinary Pathology of the Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Saulo Petinatti Pavarini1 Department of Veterinary Pathology of the Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Fabrício Souza Campos2 Laboratory of Virology, Department of Microbiology, Immunology and Parasitology, Institute of Basic Health Sciences of the Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Viviam Pignone3 Hospital Veterinary Clinics of the Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Cláudia Faraco3 Hospital Veterinary Clinics of the Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Marcelo de Souza Muccillo3 Hospital Veterinary Clinics of the Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Paulo Michel Roehe2 Laboratory of Virology, Department of Microbiology, Immunology and Parasitology, Institute of Basic Health Sciences of the Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Fernanda Viera Amorim da Costa4 Department of Animal Medicine of the Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
David Driemeier1 Department of Veterinary Pathology of the Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Universidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives This study presents the clinical, pathological, immunohistochemical and molecular characterization of 26 cats with feline chronic gingivostomatitis (FCG). Methods Oral mucosal biopsies, blood and swabs were collected from cats presenting with oral lesions. The tissue sections were submitted for histopathology and immunohistochemical analysis for feline calicivirus (FCV), feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV). The swabs were subjected to PCR analysis for FCV, and blood for FeLV and FIV. Results The main clinical findings were dysphagia (88.2%), halitosis (76.5%), sialorrhea (47.1%), weight loss (41.2%), intense oral discomfort (35.3%), oral hemorrhage (17.6%), and lackluster and fragile coat (11.8%). Gross inspection revealed bilateral lesions across the palatoglossal fold to the lateral tongue base. The lesions were diffuse, proliferative, intensely red and friable, and bled easily upon examination in 80.8% of cases. In 23.1% of cases, the lesions were multifocal to coalescent, at times forming multiple vesicles on a reddened, edematous palatoglossal fold. Microscopic examination showed that 15.4% of lesions had moderate (grade 2) and 84.6% had severe (grade 3) inflammation. Immunohistochemistry revealed the presence of FeLV antigens in the epithelium and the inflammatory infiltrate of 30.8% of the cats with FCG. FCV antigens were not detected in the FCG lesions. Conclusions and relevance The FCG cases analyzed could not be correlated with FCV. It is possible that FeLV plays a role as a causal agent of lesions in cases where the presence of the virus has been confirmed by immunohistochemistry in epithelial samples.

Indexed as

AnimalsCaliciviridaeCat DiseasesCatsFemaleGingivitisImmunodeficiency Virus, FelineImmunohistochemistryLeukemia Virus, FelineMalePolymerase Chain ReactionStomatitis

Identifiers

PMID26858258
PMCPMC11119643
OpenAlexW2266792529

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.