ArticleMalaria journal2016
Genetic diversity among Plasmodium vivax isolates along the Thai-Myanmar border of Thailand.
Article in Malaria journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 17 citations in OpenAlex.
- Genetic diversity and multiplicity of Plasmodium spp. infections in Southeast Asia: a scoping review.Osong public health and research perspectives · 2026Article
- Molecular epidemiology and genetic diversity of disappearing Plasmodium vivax in southern Thailand.Scientific reports · 2025Article
- Low Genetic Diversity ofTropical medicine and infectious disease · 2024Article
- Exploring genetic polymorphisms among Plasmodium vivax isolates from the Thai-Myanmar borders using circumsporozoite protein (pvcsp) and ookinete surface protein (pvs25) encoding genes.Parasitology research · 2024Article
- Genetic diversity and molecular evolution of Plasmodium vivax Duffy Binding Protein and Merozoite Surface Protein-1 in northwestern Thailand.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2023Article
- Genetic Diversity ofTropical medicine and infectious disease · 2023Article
- Distinct Allelic Diversity ofJournal of tropical medicine · 2023Article
- Genetic Diversity of Circumsporozoite Surface Protein ofPathogens (Basel, Switzerland) · 2022Article
- Article
- Determination of Cytochrome P450 Isoenzyme 2D6 (CYP2D6) Genotypes and Pharmacogenomic Impact on Primaquine Metabolism in an Active-Duty US Military Population.The Journal of infectious diseases · 2019Article
- Evaluation of Plasmodium vivax isolates in Thailand using polymorphic markers Plasmodium merozoite surface protein (PvMSP) 1 and PvMSP3.Parasitology research · 2018Article
- Plasmodium vivax rhomboid-like protease 1 gene diversity in Thailand.Experimental parasitology · 2017Article
- Genetic diversity of Plasmodium Vivax revealed by the merozoite surface protein-1 icb5-6 fragment.Infectious diseases of poverty · 2017Article
- Molecular and immunological analyses of confirmed Plasmodium vivax relapse episodes.Malaria journal · 2017Article
- Higher Complexity of Infection and Genetic Diversity ofThe American journal of tropical medicine and hygiene · 2017Article
- Plasmodium vivax msp-3α polymorphisms: analysis in the Indian subcontinent.Malaria journal · 2016Article
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKnowledge of the population genetics and transmission dynamics of Plasmodium vivax is crucial in predicting the emergence of drug resistance, relapse pattern and novel parasite phenotypes, all of which are relevant to the control of vivax infections. The aim of this study was to analyse changes in the genetic diversity of P. vivax genes from field isolates collected at different times along the Thai-Myanmar border.
methodsTwo hundred and fifty-four P. vivax isolates collected during two periods 10 years apart along the Thai-Myanmar border were analysed. The parasites were genotyped by nested-PCR and PCR-RFLP targeting selected polymorphic loci of Pvmsp1, Pvmsp3α and Pvcsp genes.
resultsThe total number of distinguishable allelic variants observed for Pvcsp, Pvmsp1, and Pvmsp3α was 17, 7 and 3, respectively. High genetic diversity was observed for Pvcsp (H E = 0.846) and Pvmsp1 (H E = 0.709). Of the 254 isolates, 4.3 and 14.6 % harboured mixed Pvmsp1 and Pvcsp genotypes with a mean multiplicity of infection (MOI) of 1.06 and 1.15, respectively. The overall frequency of multiple genotypes was 16.9 %. When the frequencies of allelic variants of each gene during the two distinct periods were analysed, significant differences were noted for Pvmsp1 (P = 0.018) and the Pvcsp (P = 0.033) allelic variants.
conclusionDespite the low malaria transmission levels in Thailand, P. vivax population exhibit a relatively high degree of genetic diversity along the Thai-Myanmar border of Thailand, in particular for Pvmsp1 and Pvcsp, with indication of geographic and temporal variation in frequencies for some variants. These results are of relevance to monitoring the emergence of drug resistance and to the elaboration of measures to control vivax malaria.
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