ArticleScientific reports2016
Limited Antigenic Diversity in Contemporary H7 Avian-Origin Influenza A Viruses from North America.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Molecular and ecological determinants of mammalian adaptability in avian influenza virus.Infection · 2025Review
- Antigenic Architecture of the H7N2 Influenza Virus Hemagglutinin Belonging to the North American Lineage.International journal of molecular sciences · 2023Article
- Evolution of the North American Lineage H7 Avian Influenza Viruses in Association with H7 Virus's Introduction to Poultry.Journal of virology · 2022Article
- Antigenic characterization of influenza and SARS-CoV-2 viruses.Analytical and bioanalytical chemistry · 2022Review
- Human antibody recognition of H7N9 influenza virus HA following natural infection.JCI insight · 2021Article
- Antigenic cartography reveals complexities of genetic determinants that lead to antigenic differences among pandemic GII.4 noroviruses.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Parallel evolution in the emergence of highly pathogenic avian influenza A viruses.Nature communications · 2020Article
- Genetic and antigenic characterization of H5 and H7 avian influenza viruses isolated from migratory waterfowl in Mongolia from 2017 to 2019.Virus genes · 2020Article
- Global patterns of avian influenza A (H7): virus evolution and zoonotic threats.FEMS microbiology reviews · 2019Review
- Aerosol Transmission of Gull-Origin Iceland Subtype H10N7 Influenza A Virus in Ferrets.Journal of virology · 2019Article
- Tissue tropisms opt for transmissible reassortants during avian and swine influenza A virus co-infection in swine.PLoS pathogens · 2018Article
- Severe human infection with a novel avian-origin influenza A(H7N4) virus.Science bulletin · 2018Article
- Two genetically diverse H7N7 avian influenza viruses isolated from migratory birds in central China.Emerging microbes & infections · 2018Article
- Zoonotic Risk, Pathogenesis, and Transmission of Avian-Origin H3N2 Canine Influenza Virus.Journal of virology · 2017Article
- Feral Swine in the United States Have Been Exposed to both Avian and Swine Influenza A Viruses.Applied and environmental microbiology · 2017Article
- Low-Pathogenic Influenza A Viruses in North American Diving Ducks Contribute to the Emergence of a Novel Highly Pathogenic Influenza A(H7N8) Virus.Journal of virology · 2017Article
- Continual Antigenic Diversification in China Leads to Global Antigenic Complexity of Avian Influenza H5N1 Viruses.Scientific reports · 2017Article
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12 authors.
Funding
Abstract
Subtype H7 avian-origin influenza A viruses (AIVs) have caused at least 500 confirmed human infections since 2003 and culling of >75 million birds in recent years. Here we antigenically and genetically characterized 93 AIV isolates from North America (85 from migratory waterfowl [1976-2010], 7 from domestic poultry [1971-2012], and 1 from a seal [1980]). The hemagglutinin gene of these H7 viruses are separated from those from Eurasia. Gradual accumulation of nucleotide and amino acid substitutions was observed in the hemagglutinin of H7 AIVs from waterfowl and domestic poultry. Genotype characterization suggested that H7 AIVs in wild birds form diverse and transient internal gene constellations. Serologic analyses showed that the 93 isolates cross-reacted with each other to different extents. Antigenic cartography showed that the average antigenic distance among them was 1.14 units (standard deviation [SD], 0.57 unit) and that antigenic diversity among the H7 isolates we tested was limited. Our results suggest that the continuous genetic evolution has not led to significant antigenic diversity for H7 AIVs from North America. These findings add to our understanding of the natural history of IAVs and will inform public health decision-making regarding the threat these viruses pose to humans and poultry.
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