ArticleScientific reports2016
A comparative study on the in vivo degradation of poly(L-lactide) based composite implants for bone fracture fixation.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 88 citations in OpenAlex.
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- Biodegradable Polymers in Biomedical Applications: A Review-Developments, Perspectives and Future Challenges.International journal of molecular sciences · 2023Review
- Polymersome-based protein drug delivery - quo vadis?Chemical Society reviews · 2023Review
- Effects of Sterilization and Hydrolytic Degradation on the Structure, Morphology and Compressive Strength of Polylactide-Hydroxyapatite Composites.International journal of molecular sciences · 2022Article
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- Marker-Independent Monitoring ofFrontiers in cardiovascular medicine · 2022Article
- Biological and Medical Applications of Calcium Phosphate Nanoparticles.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Review
- Accelerated degradation of HAP/PLLA bone scaffold by PGA blending facilitates bioactivity and osteoconductivity.Bioactive materials · 2021Article
- Three-dimensional printed poly (L-lactide) and hydroxyapatite composite for reconstruction of critical bone defect in rabbits.Acta cirurgica brasileira · 2021Article
- Article
- In-vivo evaluation of a partially resorbable poly l-lactic acid/ braided bioactive glass fibers reinforced composite for load bearing fracture fixation.Journal of materials science. Materials in medicine · 2020Article
- The Influence of Mucin-Based Artificial Saliva on Properties of Polycaprolactone and Polylactide.Polymers · 2019Article
- Synthetic Biodegradable Aliphatic Polyester Nanocomposites Reinforced with Nanohydroxyapatite and/or Graphene Oxide for Bone Tissue Engineering Applications.Nanomaterials (Basel, Switzerland) · 2019Review
- A Bioinspired Scaffold with Anti-Inflammatory Magnesium Hydroxide and Decellularized Extracellular Matrix for Renal Tissue Regeneration.ACS central science · 2019Article
- A comprehensive review of biodegradable synthetic polymer-ceramic composites and their manufacture for biomedical applications.Bioactive materials · 2019Review
- Effect of reaction solvent on hydroxyapatite synthesis in sol-gel process.Royal Society open science · 2017Article
- New approach in evaluation of ceramic-polymer composite bioactivity and biocompatibility.Analytical and bioanalytical chemistry · 2017Article
- Synthesis of Thermoplastic Xylan-Lactide Copolymer with Amidine-Mediated Organocatalyst in Ionic Liquid.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Composite of nano-hydroxyapatite (n-HAP) surface grafted with poly(L-lactide) (PLLA) (g-HAP) showed improved interface compatibility and mechanical property for bone fracture fixation. In this paper, in vivo degradation of n-HAP/PLLA and g-HAP/PLLA composite implants was investigated. The mechanical properties, molecular weight, thermal properties as well as crystallinity of the implants were measured. The bending strength of the n- and g-HAP/PLLA composites showed a marked reduction from an initial value of 102 and 114 MPa to 33 and 24 MPa at 36 weeks, respectively. While the bending strength of PLLA was maintained at 80 MPa at 36 weeks compared with initial value of 107 MPa. The impact strength increased over time especially for the composites. Significant differences in the molecular weight were seen among all the materials and g-HAP/PLLA appeared the fastest rate of decrease than others. Environmental scanning electron microscope (ESEM) results demonstrated that an apparently porous morphology full of pores and hollows were formed in the composites. The results indicated that the in vivo degradation of PLLA could be accelerated by the g-HAP nanoparticles. It implied that g-HAP/PLLA composites might be a candidate for human non-load bearing bone fracture fixation which needs high initial strength and fast degradation rate.
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