Evidence map›Paper›PMID 26857902›Full record

ReviewJournal of veterinary internal medicine

Equine Protozoal Myeloencephalitis: An Updated Consensus Statement with a Focus on Parasite Biology, Diagnosis, Treatment, and Prevention.

S M Reed, M Furr, D K Howe, A L Johnson, R J MacKay, J K Morrow, N Pusterla, S Witonsky

Abstract readReviewConsensus Statement
In one paragraph

Review in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Article
  2. Persistence ofFrontiers in veterinary science · 2026
    Article
  3. Review
  4. bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Co-dependent formation of thebioRxiv : the preprint server for biology · 2024
    Article
  7. Description of the parasitic fauna of a specimen ofBrazilian journal of veterinary medicine · 2024
    Article
  8. Article
  9. Article
  10. Neurologic conditions in the sport horse.Animal frontiers : the review magazine of animal agriculture · 2022
    Article
  11. Article
  12. Article
  13. Postmortem diagnoses of spinal ataxia in 316 horses in California.Journal of the American Veterinary Medical Association · 2021
    Article
  14. Equine Cervical Pain and Dysfunction: Pathology, Diagnosis and Treatment.Animals : an open access journal from MDPI · 2021
    Review
  15. Article
  16. Article
  17. Article
  18. Sidewinder gait in horses.Journal of veterinary internal medicine · 2020
    Article
  19. Article
  20. Reactivity of Horse Sera to Antigens Derived FromFrontiers in veterinary science · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

S M ReedRood and Riddle Equine Hospital, 2150 Georgetown Road, Lexington, Kentucky, 40511.
M FurrDepartment of Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK.
D K HoweDepartment of Veterinary Science, Maxwell H. Gluck Equine Research Center, University of Kentucky, Lexington, KY.
A L JohnsonNew Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA.
R J MacKayCollege of Veterinary Medicine, University of Florida, Gainesville, FL.
J K MorrowEquine Diagnostic Solutions LLC, Lexington, KY.
N PusterlaDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA.
S WitonskyVirginia-Maryland Regional College of Veterinary Medicine, Blacksburg, VA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Equine protozoal myeloencephalitis (EPM) remains an important neurologic disease of horses. There are no pathognomonic clinical signs for the disease. Affected horses can have focal or multifocal central nervous system (CNS) disease. EPM can be difficult to diagnose antemortem. It is caused by either of 2 parasites, Sarcocystis neurona and Neospora hughesi, with much less known about N. hughesi. Although risk factors such as transport stress and breed and age correlations have been identified, biologic factors such as genetic predispositions of individual animals, and parasite-specific factors such as strain differences in virulence, remain largely undetermined. This consensus statement update presents current published knowledge of the parasite biology, host immune response, disease pathogenesis, epidemiology, and risk factors. Importantly, the statement provides recommendations for EPM diagnosis, treatment, and prevention.

Indexed as

Practice Guidelines as TopicAnimalsAntiprotozoal AgentsCoccidiosisEncephalomyelitisHorse DiseasesHorsesNeosporaSarcocystisSarcocystosisAntiprotozoal AgentsEncephalitisEquine myeloencephalopathyEquine neurologicEquine protozoal diseaseMyelitisNeospora hughesiSarcocystis neurona

Identifiers

PMID26857902
PMCPMC4913613

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.