Evidence map›Paper›PMID 26857762›Full record

Trial reportEuropean journal of nutrition2017

Difference in postprandial GLP-1 response despite similar glucose kinetics after consumption of wheat breads with different particle size in healthy men.

Coby Eelderink, Martijn W J Noort, Nesli Sozer, Martijn Koehorst, Jens J Holst, Carolyn F Deacon, Jens F Rehfeld, Kaisa Poutanen, Roel J Vonk, Lizette Oudhuis and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Review
  7. Nutritional strategies to attenuate postprandial glycemic response.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022
    Review
  8. Article
  9. Review
  10. Article
  11. Boosting GLP-1 by Natural Products.Advances in experimental medicine and biology · 2021
    Article
  12. Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Coby EelderinkCenter for Medical Biomics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands. c.eelderink@umcg.nl.
Martijn W J NoortTNO Food and Nutrition, Zeist, The Netherlands.
Nesli SozerVTT Technical Research Centre of Finland, Espoo, Finland.
Martijn KoehorstDepartment of Laboratory Medicine, Center for Liver Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Jens J HolstNNF Center for Basic Metabolic Research, Department of Biomedical Sciences, The Panum Institute, University of Copenhagen, Copenhagen, Denmark.
Carolyn F DeaconNNF Center for Basic Metabolic Research, Department of Biomedical Sciences, The Panum Institute, University of Copenhagen, Copenhagen, Denmark.
Jens F RehfeldDepartment of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Kaisa PoutanenVTT Technical Research Centre of Finland, Espoo, Finland.
Roel J VonkCenter for Medical Biomics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
Lizette OudhuisTop Institute Food and Nutrition, Wageningen, The Netherlands.
Marion G PriebeCenter for Medical Biomics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeUnderlying mechanisms of the beneficial health effects of low glycemic index starchy foods are not fully elucidated yet. We varied the wheat particle size to obtain fiber-rich breads with a high and low glycemic response and investigated the differences in postprandial glucose kinetics and metabolic response after their consumption.

methodsTen healthy male volunteers participated in a randomized, crossover study, consuming

resultsDespite the attempt to obtain a bread with a low glycemic response by replacing flour by broken kernels, the glycemic response and glucose kinetics were quite similar after consumption of CB and KB. Interestingly, the glucagon-like peptide-1 (GLP-1) response was much lower after KB compared to CB (iAUC, P < 0.005). A clear postprandial increase in plasma conjugated bile acids was observed after both meals.

conclusionsSubstitution of 85 % wheat flour by broken kernels in bread did not result in a difference in glucose response and kinetics, but in a pronounced difference in GLP-1 response. Thus, changing the processing conditions of wheat for baking bread can influence the metabolic response beyond glycemia and may therefore influence health.

Indexed as

BreadPostprandial PeriodAppetiteBile Acids and SaltsBlood GlucoseBody Mass IndexCross-Over StudiesDietary FiberFlourGlucagonGlucagon-Like Peptide 1HumansIncretinsInsulinMaleParticle SizeBile Acids and SaltsBlood GlucoseDietary FiberGlucagonGlucagon-Like Peptide 1IncretinsInsulinBile acidsBread processingGlucagon-like peptide-1Glucose kineticsGlycemic indexWheat kernels

Identifiers

PMID26857762
PMCPMC5346412

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.