ArticleScientific reports2016
Gold nanoparticle-assisted all optical localized stimulation and monitoring of Ca²⁺ signaling in neurons.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 63 citations in OpenAlex.
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- Nanoparticle-based optical interfaces for retinal neuromodulation: a review.Frontiers in cellular neuroscience · 2024Review
- Neural modulation with photothermally active nanomaterials.Nature reviews bioengineering · 2023Article
- Nano-positioning and tubulin conformation contribute to axonal transport regulation of mitochondria along microtubules.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- High-precision neural stimulation through optoacoustic emitters.Neurophotonics · 2022Article
- Microfluidic Based Physical Approaches towards Single-Cell Intracellular Delivery and Analysis.Micromachines · 2021Review
- Computational Investigation of Protein Photoinactivation by Molecular Hyperthermia.Journal of biomechanical engineering · 2021Article
- Regulation of Electromagnetic Perceptive Gene Using Ferromagnetic Particles for the External Control of Calcium Ion Transport.Biomolecules · 2020Article
- Engineered nanomedicine for neuroregeneration: light emitting diode-mediated superparamagnetic iron oxide-gold core-shell nanoparticles functionalized by nerve growth factor.Nanomedicine : nanotechnology, biology, and medicine · 2019Article
- Precise cell behaviors manipulation through light-responsive nano-regulators: recent advance and perspective.Theranostics · 2019Review
- Fluorescence lifetime imaging nanoscopy for measuring Förster resonance energy transfer in cellular nanodomains.Neurophotonics · 2019Article
- A machine learning approach for online automated optimization of super-resolution optical microscopy.Nature communications · 2018Article
- Gold nanoparticle-mediated laser stimulation induces a complex stress response in neuronal cells.Scientific reports · 2018Article
- Neuro-Nano Interfaces: Utilizing Nano-Coatings and Nanoparticles to Enable Next-Generation Electrophysiological Recording, Neural Stimulation, and Biochemical Modulation.Advanced functional materials · 2018Article
- A Materials Roadmap to Functional Neural Interface Design.Advanced functional materials · 2018Article
- Roadmap on semiconductor-cell biointerfaces.Physical biology · 2018Review
- Neural Recording and Modulation Technologies.Nature reviews. Materials · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Light-assisted manipulation of cells to control membrane activity or intracellular signaling has become a major avenue in life sciences. However, the ability to perform subcellular light stimulation to investigate localized signaling has been limited. Here, we introduce an all optical method for the stimulation and the monitoring of localized Ca(2+) signaling in neurons that takes advantage of plasmonic excitation of gold nanoparticles (AuNPs). We show with confocal microscopy that 800 nm laser pulse application onto a neuron decorated with a few AuNPs triggers a transient increase in free Ca(2+), measured optically with GCaMP6s. We show that action potentials, measured electrophysiologically, can be induced with this approach. We demonstrate activation of local Ca(2+) transients and Ca(2+) signaling via CaMKII in dendritic domains, by illuminating a single or few functionalized AuNPs specifically targeting genetically-modified neurons. This NP-Assisted Localized Optical Stimulation (NALOS) provides a new complement to light-dependent methods for controlling neuronal activity and cell signaling.
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Registered trials
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