Trial reportScientific reports2016
Telomere length, genetic variants and risk of squamous cell carcinoma of the head and neck in Southeast Chinese.
Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Association between Telomere Length and Head and Neck Cancer Risk: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2024Pooled it
- Vascular endothelial growth factor polymorphisms are associated with osteosarcoma susceptibility.Oncotarget · 2016Pooled it
- Assessment of genetic susceptibility in patients with oral squamous cell carcinoma: a systematic review and meta-analysis.Communications medicine · 2026Article
- Lip, Oral Cavity, and Pharyngeal Cancers: Global Epidemiology, Risk Factors, and Prevention: A Narrative Review.Health science reports · 2025Article
- Inherited Telomere Biology Disorders: Pathophysiology, Clinical Presentation, Diagnostics, and Treatment.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2024Review
- Exploring the Susceptibility to Multiple Primary Tumors in Patients with Differentiated Thyroid Cancer.Diagnostics (Basel, Switzerland) · 2024Article
- Multi-omics analysis to screen potential therapeutic biomarkers for anti-cancer compounds.Heliyon · 2022Article
- Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers.International journal of epidemiology · 2019Article
- Telomerase Reverse Transcriptase Polymorphism rs2736100: A Balancing Act between Cancer and Non-Cancer Disease, a Meta-Analysis.Frontiers in medicine · 2018Article
- Telomere length variation in tumor cells and cancer-associated fibroblasts: potential biomarker for hepatocellular carcinoma.The Journal of pathology · 2017Article
- Article
- Genetic variants in the ZNF208 gene are associated with esophageal cancer in a Chinese Han population.Oncotarget · 2016Article
- Association of Relative Leucocyte Telomere Length and Gene Single Nucleotide Polymorphisms (Cancer genomics & proteomicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomere dysfunction participates in malignant transformation and tumorigenesis. Previous studies have explored the associations between telomere length (TL) and cancer susceptibility; however, the findings are inconclusive. The associations between genetic variants and TL have been verified by quite a few genome-wide association studies (GWAS). Yet, to date, there was no published study on the relationship between TL, related genetic variants and susceptibility to squamous cell carcinoma of the head and neck (SCCHN) in Chinese. Hence, we detected relative telomere length (RTL) by using quantitative PCR and genotyped seven selected single nucleotide polymorphisms by TaqMan allelic discrimination assay in 510 SCCHN cases and 913 controls in southeast Chinese. The results showed that RTL was significantly associated with SCCHN risk [(adjusted odds ratio (OR) = 1.19, 95% confidence interval (CI) = 1.08-1.32, P = 0.001]. Furthermore, among seven selected SNPs, only G allele of rs2736100 related to RTL in Caucasians was significantly associated with both the decreased RTL (P = 0.002) and the increased susceptibility to SCCHN in Chinese (additive model: adjusted OR = 1.17, 95%CI = 1.00-1.38, P = 0.049). These findings provide evidence that shortened TL is a risk factor for SCCHN, and genetic variants can contribute to both TL and the susceptibility to SCCHN in southeast Chinese population.
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