ArticlePediatric nephrology (Berlin, Germany)2016
A new approach to define acute kidney injury in term newborns with hypoxic ischemic encephalopathy.
Article in Pediatric nephrology (Berlin, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07743099 (Renal Oxygen Saturation Measured by Near-Infrared Spectroscopy for the Early Recognition of Acute Kidney Injury in Asphyxiated Neonates Undergoing Therapeutic Hypothermia), which is not on this map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Renal Oxygen Saturation Measured by Near-Infrared Spectroscopy for the Early Recognition of Acute Kidney Injury in Asphyxiated Neonates Undergoing Therapeutic Hypothermia: A Prospective Observational Cohort Study
Who cites it
46 citing papers in PubMed, 85 citations in OpenAlex.
- Elevated serum creatinine over the first week of life and mortality risk in extremely preterm neonates: a secondary analysis of the Preterm Erythropoietin Neuroprotection Trial (PENUT).Pediatric nephrology (Berlin, Germany) · 2026Trial
- Incidence and risk factors associated with acute kidney injury in newborns receiving therapeutic hypothermia.Pediatric nephrology (Berlin, Germany) · 2026Article
- Neonatal acute kidney injury: Reassessing diagnostic criteria for acute kidney injury in neonates with hypoxic-ischaemic encephalopathy undergoing therapeutic hypothermia.Pediatric nephrology (Berlin, Germany) · 2026Article
- From survival to surveillance: the long-term kidney legacy of preterm birth.Pediatric nephrology (Berlin, Germany) · 2026Article
- Acute kidney injury in neonates with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia: impact of diagnostic criteria and clinical predictors.Pediatric nephrology (Berlin, Germany) · 2026Article
- Incidence and risk factors of vancomycin-associated nephrotoxicity among neonates in the intensive care unit: a retrospective cohort study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Comparison of KDIGO and nRIFLE criteria for acute kidney injury in neonates with hypoxic-ischemic encephalopathy.Pediatric nephrology (Berlin, Germany) · 2026Article
- From Gestational Age-Specific Serum Creatinine Trajectories to an Interactive Clinical Interpretation Tool in Level IV NICU Infants.Research square · 2026Article
- Neonatal acute kidney injury: where are we now?Pediatric nephrology (Berlin, Germany) · 2026Review
- Serum creatinine: beyond renal function as a biomarker of adverse outcomes in premature neonates.Pediatric research · 2026Article
- Neonatal AKI Definition: Is the perfect definition attainable or even desirable? Proceedings from the First International Neonatal Nephrology Symposium.Pediatric research · 2026Article
- Establishing a reference range for serum creatinine in the neonatal population and re-defining neonatal acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2026Article
- Association between impaired renal function based on decline in serum creatinine level and brain injury in neonates with hypoxic-ischemic encephalopathy.Clinical and experimental pediatrics · 2026Article
- Evaluation of acute kidney injury in preterm infants using serum creatinine decline in comparison with KDIGO criteria.Pediatric nephrology (Berlin, Germany) · 2025Article
- Multi-organ dysfunction across the neonatal encephalopathy spectrum.Pediatric research · 2025Article
- Incidence of and risk factors for acute kidney injury in neonates with congenital diaphragmatic hernia.European journal of pediatrics · 2025Article
- Impact of acute kidney injury and dysnatremia on length of stay in infants after cardiac surgery.Pediatric nephrology (Berlin, Germany) · 2025Article
- The overlooked subgroup: preterm neonates with elevated serum creatinine outside neonatal AKI criteria.Pediatric research · 2025Article
- Evaluation of risk factors and outcomes of neonates with hypoxic ischemic encephalopathy and acute kidney injury.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Employing a Haemodynamic Score to Predict Acute Kidney Injury in Infants With Patent Ductus Arteriosus.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCurrent definitions of acute kidney injury (AKI) are not sufficiently sensitive to identify all newborns with AKI during the first week of life.
methodsTo determine whether the rate of decline of serum creatinine (SCr) during the first week of life can be used to identify newborns with AKI, we reviewed the medical records of 106 term neonates at risk of AKI who were treated with hypothermia for hypoxic ischemic encephalopathy (HIE).
resultsOf the newborns enrolled in the study, 69 % showed a normal rate of decline of SCr to ≥50 % and/or reached SCr levels of ≤0.6 mg/dl before the 7th day of life, and therefore had an excellent clinical outcome (control group). Thirteen newborns with HIE (12 %) developed AKI according to an established neonatal definition (AKI-KIDGO group), and an additional 20 newborns (19 %) showed a rate of decline of SCr of <33, <40, and <46 % from birth to days 3, 5, or 7 of life, respectively (delayed rise in estimated SCr clearance group). Compared to the control group, newborns in the other two groups required more days of mechanical ventilation and vasopressor drugs and had higher gentamicin levels, more fluid overload, lower urinary epidermal growth factor levels, and a prolonged length of stay.
conclusionsThe rate of decline of SCr provides a sensitive approach to identify term newborns with AKI during the first week of life.
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