ArticleMolecular psychiatry2016
Assessing the genetic overlap between BMI and cognitive function.
Article in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Effects of Food Advertisements on Food Intake and Neural Activity: A Systematic Review and Meta-Analysis of Recent Experimental Studies.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- Executive Functions in Predicting Weight Loss and Obesity Indicators: A Meta-Analysis.Frontiers in psychology · 2020Pooled it
- Neurobehavioral correlates of obesity are largely heritable.Proceedings of the National Academy of Sciences of the United States of America · 2018Trial
- Associations between polygenic risk for obesity, body mass index and cognitive performance: Age as moderating factor.Brain, behavior, & immunity - health · 2026Article
- Weight-adjusted waist index and cognitive impairment in older adults: A nationwide longitudinal cohort study.Medicine · 2026Article
- Association of genetic scores related to insulin resistance with neurological outcomes in ancestrally diverse cohorts from the Trans-Omics for Precision Medicine (TOPMed) program.Communications biology · 2025Article
- Association between relative fat mass and cognitive function among US older men: NHANES 2011-2014.Lipids in health and disease · 2025Article
- Relationship between cognitive function and weight-adjusted waist index in people ≥ 60 years old in NHANES 2011-2014.Aging clinical and experimental research · 2024Article
- Association between weight-adjusted-waist index and cognitive decline in US elderly participants.Frontiers in nutrition · 2024Article
- Potential application of elastic nets for shared polygenicity detection with adapted threshold selection.The international journal of biostatistics · 2023Article
- Association between Nonfood Pre- or Probiotic Use and Cognitive Function: Results from NHANES 2011-2014.Nutrients · 2023Article
- Sex Differences in the Associations of Obesity with Tau, Amyloid PET, and Cognitive Outcomes in Preclinical Alzheimer's Disease: Cross-Sectional A4 Study.Journal of Alzheimer's disease : JAD · 2023Article
- Correlations Between Endocrine Hormones and Cognitive Function in Patients with Obesity: a Cross-sectional Study.Obesity surgery · 2022Article
- Sexual dimorphism in the relationship betweenFrontiers in aging neuroscience · 2022Article
- Favourable Lifestyle Protects Cognitive Function in Older Adults With High Genetic Risk of Obesity: A Prospective Cohort Study.Frontiers in molecular neuroscience · 2022Article
- Integration of genetic, transcriptomic, and clinical data provides insight into 16p11.2 and 22q11.2 CNV genes.Genome medicine · 2021Article
- Body Mass Index and Polygenic Risk for Alzheimer's Disease Predict Conversion to Alzheimer's Disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- The dynamic association between body mass index and cognition from midlife through late-life, and the effect of sex and genetic influences.Scientific reports · 2021Article
- Investigating the effects of genetic risk of schizophrenia on behavioural traits.NPJ schizophrenia · 2021Article
- Association Between Genetic Risks for Obesity and Working Memory in Children.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Obesity and low cognitive function are associated with multiple adverse health outcomes across the life course. They have a small phenotypic correlation (r=-0.11; high body mass index (BMI)-low cognitive function), but whether they have a shared genetic aetiology is unknown. We investigated the phenotypic and genetic correlations between the traits using data from 6815 unrelated, genotyped members of Generation Scotland, an ethnically homogeneous cohort from five sites across Scotland. Genetic correlations were estimated using the following: same-sample bivariate genome-wide complex trait analysis (GCTA)-GREML; independent samples bivariate GCTA-GREML using Generation Scotland for cognitive data and four other samples (n=20 806) for BMI; and bivariate LDSC analysis using the largest genome-wide association study (GWAS) summary data on cognitive function (n=48 462) and BMI (n=339 224) to date. The GWAS summary data were also used to create polygenic scores for the two traits, with within- and cross-trait prediction taking place in the independent Generation Scotland cohort. A large genetic correlation of -0.51 (s.e. 0.15) was observed using the same-sample GCTA-GREML approach compared with -0.10 (s.e. 0.08) from the independent-samples GCTA-GREML approach and -0.22 (s.e. 0.03) from the bivariate LDSC analysis. A genetic profile score using cognition-specific genetic variants accounts for 0.08% (P=0.020) of the variance in BMI and a genetic profile score using BMI-specific variants accounts for 0.42% (P=1.9 × 10(-7)) of the variance in cognitive function. Seven common genetic variants are significantly associated with both traits at P<5 × 10(-5), which is significantly more than expected by chance (P=0.007). All these results suggest there are shared genetic contributions to BMI and cognitive function.
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