ArticleNucleic acids research2016
Telomere-binding protein regulates the chromosome ends through the interaction with histone deacetylases in Arabidopsis thaliana.
Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Exploring the evolution of the histone deacetylase 2 (HD2) gene family in plants and the role of AtHDT4 in cadmium stress response in Arabidopsis thaliana.Plant cell reports · 2026Article
- TRB proteins in moss reveal their evolutionarily conserved roles in plant development and telomere maintenance.The Plant journal : for cell and molecular biology · 2025Article
- Telomeres: an organized string linking plants and mammals.Biology direct · 2024Review
- The H1/H5 domain contributes to OsTRBF2 phase separation and gene repression during rice development.The Plant cell · 2024Article
- The TELOMERE REPEAT BINDING proteins TRB4 and TRB5 function as transcriptional activators of PRC2-controlled genes to regulate plant development.Plant communications · 2024Article
- Completing the TRB family: newly characterized members show ancient evolutionary origins and distinct localization, yet similar interactions.Plant molecular biology · 2023Article
- Genome-Wide Identification of Histone Deacetylases and Their Roles Related with Light Response in Tartary Buckwheat (International journal of molecular sciences · 2023Article
- Arabidopsis TRB proteins function in H3K4me3 demethylation by recruiting JMJ14.Nature communications · 2023Article
- Beyond transcription factors: more regulatory layers affecting soybean gene expression under abiotic stress.Genetics and molecular biology · 2023Article
- Plant-specific HDT family histone deacetylases are nucleoplasmins.The Plant cell · 2022Article
- MYB44-ENAP1/2 restricts HDT4 to regulate drought tolerance in Arabidopsis.PLoS genetics · 2022Article
- Histone Modifications Form Epigenetic Regulatory Networks to Regulate Abiotic Stress Response.Plant physiology · 2020Article
- Epigenetic aspects of telomeric chromatin in Arabidopsis thaliana.BMB reports · 2019Review
- Review
- Telomere association of Oryza sativa telomere repeat-binding factor like 1 and its roles in telomere maintenance and development in rice, Oryza sativa L.BMB reports · 2018Article
- Characterization and subcellular localization of histone deacetylases and their roles in response to abiotic stresses in soybean.BMC plant biology · 2018Article
- The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing.The EMBO journal · 2018Article
- Telobox motifs recruit CLF/SWN-PRC2 for H3K27me3 deposition via TRB factors in Arabidopsis.Nature genetics · 2018Article
- The Distinct Roles of Class I and II RPD3-Like Histone Deacetylases in Salinity Stress Response.Plant physiology · 2017Article
- Telomere- and Telomerase-Associated Proteins and Their Functions in the Plant Cell.Frontiers in plant science · 2016Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomeres are nucleoprotein complexes at the end of eukaryotic chromosomes. Many telomere-binding proteins bind to telomeric repeat sequences and further generate T-loops in animals. However, it is not clear if they regulate telomere organization using epigenetic mechanisms and how the epigenetic molecules are involved in regulating the telomeres. Here, we show direct interactions between the telomere-binding protein, AtTRB2 and histone deacetylases, HDT4 and HDA6, in vitro and in vivo AtTRB2 mediates the associations of HDT4 and HDA6 with telomeric repeats. Telomere elongation is found in AtTRB2, HDT4 and HDA6 mutants over generations, but also in met1 and cmt3 DNA methyltransferases mutants. We also characterized HDT4 as an Arabidopsis H3K27 histone deacetylase. HDT4 binds to acetylated peptides at residue K27 of histone H3 in vitro, and deacetylates this residue in vivo Our results suggest that AtTRB2 also has a role in the regulation of telomeric chromatin as a possible scaffold protein for recruiting the epigenetic regulators in Arabidopsis, in addition to its telomere binding and length regulation activity. Our data provide evidences that epigenetic molecules associate with telomeres by direct physical interaction with telomere-binding proteins and further regulate homeostasis of telomeres in Arabidopsis thaliana.
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