Evidence map›Paper›PMID 26857507›Full record

ArticleThe American journal of pathology2016

Clinicopathologic, Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the United Arab Emirates, April 2014.

Dianna L Ng, Farida Al Hosani, M Kelly Keating, Susan I Gerber, Tara L Jones, Maureen G Metcalfe, Suxiang Tong, Ying Tao, Negar N Alami, Lia M Haynes and 6 more

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 254 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
254citing papers in PubMed, 11 pooled it
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

254 citing papers in PubMed, 11 syntheses or guidelines pooled it, 401 citations in OpenAlex.

  1. Pooled it
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  3. Autopsy findings in COVID-19-related deaths: a literature review.Forensic science, medicine, and pathology · 2021
    Pooled it
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  7. COVID-19 and Major Organ Thromboembolism: Manifestations in Neurovascular and Cardiovascular Systems.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2021
    Pooled it
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  10. Guideline
  11. Guideline
  12. Article
  13. Variable DPP4 expression in multiciliated cells of the human nasal epithelium as a determinant for MERS-CoV tropism.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  19. Plitidepsin as an Immunomodulator against Respiratory Viral Infections.Journal of immunology (Baltimore, Md. : 1950) · 2024
    Article
  20. Review

194 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Dianna L NgInfectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Farida Al HosaniCommunicable Diseases Department, Abu Dhabi, United Arab Emirates.
M Kelly KeatingInfectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Susan I GerberEpidemiology Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Tara L JonesInfectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Maureen G MetcalfeInfectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Suxiang TongGastroenteritis and Respiratory Virus Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Ying TaoGastroenteritis and Respiratory Virus Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Negar N AlamiEpidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia; International Research and Programs Branch, National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Lia M HaynesOffice of the Director, Centers for Disease Control and Prevention, Atlanta, Georgia.
Mowafaq Ali MuteiEmergency and Disaster Department, Abu Dhabi, United Arab Emirates.
Laila Abdel-WarethPathology and Laboratory Medicine Institute, Cleveland Clinic, Abu Dhabi, United Arab Emirates.
Timothy M UyekiInfluenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia.
David L SwerdlowNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Maha BarakatHealth Authority-Abu Dhabi, Abu Dhabi, United Arab Emirates.
Sherif R ZakiInfectious Diseases Pathology Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia. Electronic address: szaki@cdc.gov.
Centers for Disease Control and Prevention · USNational Center for Emerging and Zoonotic Infectious Diseases · USEmirates Foundation · AEEpidemic Intelligence Service · USOffice of the Director · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) infection causes an acute respiratory illness and is associated with a high case fatality rate; however, the pathogenesis of severe and fatal MERS-CoV infection is unknown. We describe the histopathologic, immunohistochemical, and ultrastructural findings from the first autopsy performed on a fatal case of MERS-CoV in the world, which was related to a hospital outbreak in the United Arab Emirates in April 2014. The main histopathologic finding in the lungs was diffuse alveolar damage. Evidence of chronic disease, including severe peripheral vascular disease, patchy cardiac fibrosis, and hepatic steatosis, was noted in the other organs. Double staining immunoassays that used anti-MERS-CoV antibodies paired with immunohistochemistry for cytokeratin and surfactant identified pneumocytes and epithelial syncytial cells as important targets of MERS-CoV antigen; double immunostaining with dipeptidyl peptidase 4 showed colocalization in scattered pneumocytes and syncytial cells. No evidence of extrapulmonary MERS-CoV antigens were detected, including the kidney. These results provide critical insights into the pathogenesis of MERS-CoV in humans.

Indexed as

Coronavirus InfectionsDipeptidyl Peptidase 4Fatal OutcomeHumansImmunohistochemistryLungMaleMiddle AgedMiddle East Respiratory Syndrome CoronavirusRadiographyUnited Arab EmiratesDipeptidyl Peptidase 4

Identifiers

PMID26857507
PMCPMC7093852
OpenAlexW2256430766

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.