ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016
Clinical impact of circulating microRNAs as blood-based marker in childhood acute lymphoblastic leukemia.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- The Potential Diagnostic Accuracy of Circulating MicroRNAs for Leukemia: A Meta-Analysis.Technology in cancer research & treatmentPooled it
- Nano optical (bio)sensing platforms for early detection of pediatric cancer.Mikrochimica acta · 2025Review
- Review
- Circulating Biomarkers Associated with the Diagnosis and Prognosis of B-Cell Progenitor Acute Lymphoblastic Leukemia.Cancers · 2023Review
- MiRNAs in Hematopoiesis and Acute Lymphoblastic Leukemia.International journal of molecular sciences · 2023Review
- Review
- Review
- PI3 kinase signaling pathway in hematopoietic cancers: A glance in miRNA's role.Journal of clinical laboratory analysis · 2021Review
- Regulatory noncoding RNAs: potential biomarkers and therapeutic targets in acute myeloid leukemia.American journal of blood research · 2021Article
- Exosomal MiRNAs in Pediatric Cancers.International journal of molecular sciences · 2019Review
- Review
- [Value of S100A8 in evaluating the prognosis of children with acute lymphoblastic leukemia].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Article
- Bayesian multilevel model of micro RNA levels in ovarian-cancer and healthy subjects.PloS one · 2019Article
- Expression and Role of MicroRNA-663b in Childhood Acute Lymphocytic Leukemia and its Mechanism.Open medicine (Warsaw, Poland) · 2019Article
- Circulating microRNA as diagnostic biomarkers for haematological cancers: a systematic review and meta-analysis.Cancer management and research · 2019Article
- MiRNA Dysregulation in Childhood Hematological Cancer.International journal of molecular sciences · 2018Review
- Pooling-analysis for diagnostic and prognostic value of MiRNA-100 in various cancers.Oncotarget · 2017Review
- Clinical significance of microRNAs in chronic and acute human leukemia.Molecular cancer · 2016Review
- Translating microRNAs into biomarkers: What is new for pediatric cancer?Medical oncology (Northwood, London, England) · 2016Review
- Advancements in the Regulatory Role of microRNAs in Childhood Acute Lymphoblastic Leukemia: Mechanisms and Clinical Implications.Technology in cancer research & treatmentReview
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aberrant microRNA (miRNA) expression participates in childhood acute lymphoblastic leukemia (ALL). This study aimed to investigate the expression of miRNA-100, miRNA-196a, and miRNA-146a among childhood ALL and study their correlation with other hematological parameters and different phenotypes. Peripheral blood mononuclear cells (PMNCs) were obtained from 85 childhood ALL and 25 healthy children for the detection of miRNA expression using quantitative real-time PCR. Significant higher median levels were reported for ALL compared to control children. The diagnostic efficacy for miRNA-146a was superior as both sensitivity and specificity were absolute. A significant correlation was observed between higher expression of miRNA-100 and lower platelet and lymphocyte counts; high expression of miRNA-146a showed significant correlation with low total leukocyte count (TLC) and lymphocyte counts. Significant relation was reported between studied miRNAs and different phenotyping. miRNA-100, miRNA-196a, and miRNA-146a have significant role in childhood ALL leukemogenesis, and they may be useful as biological diagnostic molecular markers.
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