ArticleScientific reports2016
Genome stability of Propionibacterium acnes: a comprehensive study of indels and homopolymeric tracts.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 55 citations in OpenAlex.
- DistinctFrontiers in microbiomes · 2024Article
- Genetic and Functional Analyses of Cutibacterium Acnes Isolates Reveal the Association of a Linear Plasmid with Skin Inflammation.The Journal of investigative dermatology · 2024Article
- Functional divergence of a bacterial enzyme promotes healthy or acneic skin.Nature communications · 2023Article
- Phenotypic and Genotypic Characterization ofMicroorganisms · 2023Article
- Treatment response to isotretinoin correlates with specific shifts in Cutibacterium acnes strain composition within the follicular microbiome.Experimental dermatology · 2023Article
- Evolution of the facial skin microbiome during puberty in normal and acne skin.Journal of the European Academy of Dermatology and Venereology : JEADV · 2023Article
- Skin dysbiosis and Cutibacterium acnes biofilm in inflammatory acne lesions of adolescents.Scientific reports · 2022Article
- Engineering selectivity of Cutibacterium acnes phages by epigenetic imprinting.PLoS pathogens · 2022Article
- Anatomy promotes neutral coexistence of strains in the human skin microbiome.Cell host & microbe · 2022Article
- Comparative Genome Analysis Reveals Accumulation of Single-Nucleotide Repeats in PathogenicCurrent issues in molecular biology · 2022Article
- Comparative Genomic Analyses and CRISPR-Cas Characterization ofFrontiers in microbiology · 2021Article
- A Janus-Faced Bacterium: Host-Beneficial and -Detrimental Roles ofFrontiers in microbiology · 2021Review
- Metagenomic growth rate inferences of strains in situ.Science advances · 2020Article
- Red-Brown Pigmentation ofMicroorganisms · 2019Article
- Review
- Role of phage ϕ1 in two strains of Salmonella Rissen, sensitive and resistant to phage ϕ1.BMC microbiology · 2018Article
- Host-microbiome interactions and recent progress into understanding the biology of acne vulgaris.Microbiome · 2018Review
- Clinical and Biological Features of Cutibacterium (Formerly Propionibacterium)Clinical microbiology reviews · 2018Review
- Article
- Platelet activation and aggregation by the opportunistic pathogen Cutibacterium (Propionibacterium) acnes.PloS one · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a species-wide comparative analysis of 90 genomes of Propionibacterium acnes that represent the known diversity of the species. Our results are augmented by six high-quality genomes and a manual investigation of all gene-sized indels found in the strains. Overall, the order of genes is conserved throughout the species. A public sybil database for easy comparative analysis of the 90 genomes was established. The analysis of indels revealed a total of 66 loci of non-core genes that correlate with phylogenetic clades. No gene was strain-specific in agreement with our conclusion that the P. acnes pan-genome is closed. An exhaustive search for homopolymeric tracts (HPTs) identified a total of 54 variable-length HPTs almost exclusively of guanine/cytosines located between genes or affecting the reading frame of genes. The repeat variation was consistent with phylogenetic clades suggesting slow accumulation over time rather than active modification. By transcriptome analysis we demonstrate how an HPT variation can affect the gene expression levels. Selected cases of both indels and HPTs are described. The catalogued data and the public P. acnes Sybil database provide a solid foundation for generating hypotheses and facilitate comparative genetic analyses in future P. acnes research.
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