ArticleMolecular and cellular pediatrics2016
The clinical consequences of sucrase-isomaltase deficiency.
Article in Molecular and cellular pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- α-Glucosidase-driven metabolism as a potential therapeutic vulnerability inFrontiers in microbiology · 2026Review
- Microbiome affects mice metabolic homeostasis via differential regulation of gene expression in the brain and gut.Physiological reports · 2025Article
- Congenital Sucrase-Isomaltase Deficiency: Same Mutation with Different Clinical Presentations.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024Article
- Healthcare Burden in Greenland of Gastrointestinal Symptoms in Adults with Inherited Loss of Sucrase-Isomaltase Function.The application of clinical genetics · 2024Article
- Intestinal Disaccharidase Deficiency in Adults: Evaluation and Treatment.Current gastroenterology reports · 2023Review
- Nutritional strategies to attenuate postprandial glycemic response.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Review
- Mechanisms Underlying Food-Triggered Symptoms in Disorders of Gut-Brain Interactions.The American journal of gastroenterology · 2022Review
- Chronic Diarrhea in an Infant With Malrotation: A Diagnostic Dilemma.JPGN reports · 2022Article
- The patient journey to diagnosis and treatment of congenital sucrase-isomaltase deficiency.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Observational
- Sucrase-Isomaltase Deficiency Causing Persistent Bloating and Diarrhea in an Adult Female.Cureus · 2021Article
- NGS Gene Panel Analysis Revealed Novel Mutations in Patients with Rare Congenital Diarrheal Disorders.Diagnostics (Basel, Switzerland) · 2021Article
- Sucrase-Isomaltase Deficiency as a Potential Masquerader in Irritable Bowel Syndrome.Digestive diseases and sciences · 2020Article
- Food Intolerances.Nutrients · 2019Review
- Diet and Functional Gastrointestinal Disorders in Children. Is the Focus on Food Exaggerated?Nutrients · 2019Article
- The Role of Disaccharidase Deficiencies in Functional Abdominal Pain Disorders-A Narrative Review.Nutrients · 2018Review
- Enzyme therapy for functional bowel disease-like post-prandial distress.Journal of digestive diseases · 2018Review
- Variable Use of Disaccharidase Assays When Evaluating Abdominal Pain.Gastroenterology & hepatology · 2018Article
- Review
- Structure-function analysis of human sucrase-isomaltase identifies key residues required for catalytic activity.The Journal of biological chemistry · 2017Article
- Molecular biology of the gut.Molecular and cellular pediatrics · 2016Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary sucrase-isomaltase deficiency, originally thought to be a homozygous recessive disorder, has been found to have numerous genetic variants that alone or in combination (compound heterozygosity) express varying degrees of clinical illness, most commonly causing chronic diarrhea, abdominal pain, and bloating. These symptoms are also present with secondary sucrase-isomaltase deficiency. Recent investigations are providing evidence that sucrase-isomaltase deficiency is more prevalent and of greater clinical significance than previously suspected. Further research is required to correlate the specific genotypes and phenotypes with their clinical expressions and to determine the most appropriate treatment algorithm for these patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.