Evidence map›Paper›PMID 26857066›Full record

ArticleJournal of the American Heart Association2016

Durable Benefits of Cellular Postconditioning: Long-Term Effects of Allogeneic Cardiosphere-Derived Cells Infused After Reperfusion in Pigs with Acute Myocardial Infarction.

Hideaki Kanazawa, Eleni Tseliou, James F Dawkins, Geoffrey De Couto, Romain Gallet, Konstantinos Malliaras, Kristine Yee, Michelle Kreke, Ileana Valle, Rachel R Smith and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Cardiac Cell Therapy: Insights into the Mechanisms of Tissue Repair.International journal of molecular sciences · 2021
    Review
  8. Article
  9. Review
  10. Evaluating Novel Targets of Ischemia Reperfusion Injury in Pig Models.International journal of molecular sciences · 2019
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Exosomes and cardioprotection - A critical analysis.Molecular aspects of medicine · 2018
    Review
  17. Article
  18. Article
  19. Article
  20. Is Cardioprotection Dead?Circulation · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Hideaki KanazawaCedars-Sinai Heart Institute, Los Angeles, CA Department of Cardiology, Keio University School of Medicine, Shinjuku Tokyo, Japan.
Eleni TseliouCedars-Sinai Heart Institute, Los Angeles, CA.
James F DawkinsCedars-Sinai Heart Institute, Los Angeles, CA.
Geoffrey De CoutoCedars-Sinai Heart Institute, Los Angeles, CA.
Romain GalletCedars-Sinai Heart Institute, Los Angeles, CA.
Konstantinos MalliarasCedars-Sinai Heart Institute, Los Angeles, CA.
Kristine YeeCedars-Sinai Heart Institute, Los Angeles, CA.
Michelle KrekeCapricor Inc., Los Angeles, CA.
Ileana ValleCapricor Inc., Los Angeles, CA.
Rachel R SmithCedars-Sinai Heart Institute, Los Angeles, CA Capricor Inc., Los Angeles, CA.
Ryan C MiddletonCedars-Sinai Heart Institute, Los Angeles, CA.
Chak-Sum HoGift of Life Michigan, Ann Arbor, MI.
Rohan DharmakumarCedars-Sinai Biomedical Imaging Research Institute, Los Angeles, CA.
Debiao LiCedars-Sinai Biomedical Imaging Research Institute, Los Angeles, CA.
Raj R MakkarCedars-Sinai Heart Institute, Los Angeles, CA.
Keiichi FukudaDepartment of Cardiology, Keio University School of Medicine, Shinjuku Tokyo, Japan.
Linda MarbánCedars-Sinai Heart Institute, Los Angeles, CA Capricor Inc., Los Angeles, CA.
Eduardo MarbánCedars-Sinai Heart Institute, Los Angeles, CA eduardo.marban@csmc.edu.
Capricor Therapeutics (United States) · USCedars-Sinai Medical Center · USFukuda Denshi (Japan) · JPGift of Life Michigan · USKeio University · JP

Funding

Safety and Efficacy of Allogeneic Cardiosphere-derived Stem Cells After MIRC3HL103356 · NHLBI · CAPRICOR, INC. · PI MARBAN, LINDA, SMITH, RACHEL RUCKDESCHEL · 2010 to 2010
$3.0M
NHLBI NIH HHS HL103356
6 · The paper itself

Abstract

backgroundInfusion of allogeneic cardiosphere-derived cells (allo-CDCs) postreperfusion elicits cardioprotective cellular postconditioning in pigs with acute myocardial infarction. However, the long-term effects of allo-CDCs have not been assessed. We performed a placebo-controlled pivotal study for long-term evaluation, as well as shorter-term mechanistic studies. METHODS AND

resultsMinipigs underwent 1.5-hour mid-left anterior descending balloon occlusion followed by reperfusion and were randomized to receive intracoronary allo-CDCs or vehicle 30 minutes postreperfusion. Left ventriculography (LVG) demonstrated preserved ejection fraction (EF) and attenuation of LV remodeling in CDC-treated pigs. Pigs underwent cardiac magnetic resonance imaging (MRI) and LVG 1 hour and 8 weeks after therapy to evaluate efficacy. MRI showed improvement of EF and attenuation of LV remodeling immediately after allo-CDC infusion. In addition, allo-CDCs improved regional function and decreased hypertrophy 2 months post-treatment. Histological analysis revealed increased myocardial salvage index, enhanced vascularity, sustained reductions in infarct size/area at risk and scar transmurality, and attenuation of collagen deposition in the infarct zone of allo-CDC-treated pigs at 2 months. Allo-CDCs did not evoke lymphohistiocytic infiltration or systemic humoral memory response. Short-term experiments designed to probe mechanism revealed antiapoptotic effects of allo-CDCs on cardiomyocytes and increases in cytoprotective macrophages, but no increase in overall inflammatory cell infiltration 2 hours after cell therapy.

conclusionsAllo-CDC infusion postreperfusion is safe, improves cardiac function, and attenuates scar size and remodeling. The favorable effects persist for at least 2 months after therapy. Thus, cellular postconditioning confers not only acute cardioprotection, but also lasting structural and functional benefits.

Indexed as

Myocardial ReperfusionAnimalsApoptosisBiopsyCells, CulturedDisease Models, AnimalMacrophagesMagnetic Resonance ImagingMyocardial InfarctionMyocardial Reperfusion InjuryMyocardiumMyocytes, CardiacStroke VolumeSwineSwine, MiniatureTime Factorsallogeneic transplantationcardioprotective effectcardiosphere‐derived cells

Identifiers

PMID26857066
PMCPMC4802479
OpenAlexW2267503251

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.