ArticleScientific reports2016
Bidirectional associations between rheumatoid arthritis and depression: a nationwide longitudinal study.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 2 of them syntheses that pooled it.
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Who cites it
77 citing papers in PubMed, 2 syntheses or guidelines pooled it, 153 citations in OpenAlex.
- Elucidating the bidirectional association between autoimmune diseases and depression: a systematic review and meta-analysis.BMJ mental health · 2024Pooled it
- Assessment of bidirectional relationships between depression and rheumatoid arthritis among adults: a two-sample Mendelian randomization study.Clinical rheumatology · 2023Pooled it
- Increased Serum Levels of Brain-Derived Neurotrophic Factor Contribute to Inflammatory Responses in Patients with Rheumatoid Arthritis.International journal of molecular sciences · 2021Trial
- Risk of misclassification of rheumatoid arthritis activity in patients with depression: a prospective ultrasound study.Clinical rheumatology · 2026Article
- Comorbidity risk characteristics of rheumatoid arthritis in the context of depression-associated lipid metabolism.Frontiers in immunology · 2026Article
- Homocysteine as a biomarker in arthritis and depression: Evidence from NHANES and gene expression studies.SAGE open medicine · 2026Article
- Analysis of anticancer drug associated adverse reactions in depressive patients from vigibase.Scientific reports · 2025Article
- Comparison of depression risk and depression-related ambulatory care utilization in sarcopenia patients with and without Chinese herbal medicine.World journal of psychiatry · 2025Article
- Immunometabolic and brain structural alterations mediate increased risk of brain diseases in rheumatoid arthritis patients.Translational psychiatry · 2025Article
- Depression and incidence of inflammation-related physical health conditions: a cohort study in UK Biobank.BMC psychiatry · 2025Article
- Experiences With Complementary and Integrative Health Among People With Rheumatoid Arthritis and Systemic Lupus Erythematosus: A Qualitative Study.The Journal of rheumatology · 2025Article
- Health-related quality of life among patients with rheumatoid arthritis in Zanzibar: a prospective cohort study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Association of TNF-α and IL-6 Concentrations with Depression in Patients with Rheumatoid Arthritis.Current issues in molecular biology · 2025Article
- Comorbidity in incident rheumatoid arthritis: a nationwide case-control study with bidirectional follow-up.Rheumatology (Oxford, England) · 2025Article
- Mediating Role of Self-Efficacy in the Association Between Fatigue and Depressive Symptoms in Females with Rheumatoid Arthritis.Medicina (Kaunas, Lithuania) · 2025Article
- Causal Relationship Between Autoimmune Arthritis and Temporomandibular Disorders.International dental journal · 2025Article
- The Combined Treatment of Chinese Herbal Medicines Is Correlated with a Lower Risk of Rheumatoid Arthritis in Patients with Depression: Evidence from a Population-Based Patient-Control Study.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Psychiatric morbidity in people with autoimmune arthritides as a model of inflammatory mechanisms in mental disorders.BMJ mental health · 2025Article
- Trends in Anxiety and Depression Among Individuals With Rheumatoid Arthritis: A Population-Based Study.The Journal of rheumatology · 2025Article
- Application of Elastic networks and Bayesian networks to explore influencing factors associated with arthritis in middle-aged and older adults in the Chinese community.Frontiers in public health · 2025Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid arthritis (RA) and depression may be associated with each other pathophysiologically, but few studies have been conducted on the interplay between these two diseases using longitudinal measurement. Therefore, we used the National Health Insurance Research Database of Taiwan to investigate the bidirectional associations between RA and depression. One cohort was included to analyze RA predicting the onset of depression and a second cohort for analysis of depression predicting RA. A sex- and age-matched control group was included for both. The incidence of depression in RA subjects was higher than in non-RA subjects [15.69 vs. 8.95 per 1,000 person-years (PYs)], with an adjusted hazard ratios (HRs) of 1.69 [95% confidence interval (CI), 1.51-1.87]. The incidence of RA was higher in depressed than non-depressed individuals (2.07 vs. 1.21 per 1,000 PYs), with an adjusted HRs of 1.65 (95% CI, 1.41-1.77). This population-based cohort study suggested strong bidirectional relationships between RA and depression. Healthcare providers are recommended to facilitate the implementation of more effective therapeutic interventions to achieve favorable prognosis, especially for those with new-onset or younger cases.
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