Evidence map›Paper›PMID 26857007›Full record

ArticleAnnals of biomedical engineering2016

Two-Point Stretchable Electrode Array for Endoluminal Electrochemical Impedance Spectroscopy Measurements of Lipid-Laden Atherosclerotic Plaques.

René R Sevag Packard, XiaoXiao Zhang, Yuan Luo, Teng Ma, Nelson Jen, Jianguo Ma, Linda L Demer, Qifa Zhou, James W Sayre, Rongsong Li and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Electrochemical impedance spectroscopy unmasks high-risk atherosclerotic features in human coronary artery disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  2. Invasive electrochemical impedance spectroscopy with phase delay for experimental atherosclerosis phenotyping.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

René R Sevag PackardDivision of Cardiology, Department of Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, CA, 90073, USA.
XiaoXiao ZhangElectrical and Mechanical Engineering, California Institute of Technology, Pasadena, CA, USA.
Yuan LuoElectrical and Mechanical Engineering, California Institute of Technology, Pasadena, CA, USA.
Teng MaDepartment of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Nelson JenDepartment of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California, Los Angeles, CA, 90073, USA.
Jianguo MaDivision of Cardiology, Department of Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, CA, 90073, USA.
Linda L DemerDivision of Cardiology, Department of Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, CA, 90073, USA.
Qifa ZhouDepartment of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
James W SayreDepartment of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA, USA.
Rongsong LiDivision of Cardiology, Department of Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, CA, 90073, USA.
Yu-Chong TaiElectrical and Mechanical Engineering, California Institute of Technology, Pasadena, CA, USA.
Tzung K HsiaiDivision of Cardiology, Department of Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, CA, 90073, USA. thsiai@mednet.ucla.edu.
University of California, Los Angeles · USCalifornia Institute of Technology · USSamueli Institute · USUniversity of Southern California · USRonald Reagan UCLA Medical Center · US

Funding

CARDIOVASCULAR SCIENTIST TRAINING PROGRAMT32HL007895 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHIVKUMAR, KALYANAM, WATSON, KAROL E · 1998 to 2023
$9.2M
Linking Spatial Variations Shear Stress-Oxidative StressR01HL083015 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HSIAI, TZUNG K · 2006 to 2015
$3.9M
Shear Stress and Light-Sheets to Study Cardiac TrabeculationR01HL129727 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K, MARSDEN, ALISON L · 2015 to 2024
$3.5M
Electronica Impedance to Access Metabolically Active PlaqueR01HL118650 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K · 2014 to 2022
$3.3M
Micro-Sensors to Study Electrical and Mechanical Coupling of Injured MyocardiumR01HL111437 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HSIAI, TZUNG K, XU, XIAOLEI · 2012 to 2020
$3.1M
Electrical Biophysical Forces Impact Cardiac MorphogenesisR01HD069305 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHI, NEIL C · 2011 to 2015
$1.6M
NHLBI NIH HHS R01 HL083015NHLBI NIH HHS R01 HL111437NHLBI NIH HHS R01 HL118650NHLBI NIH HHS R01 HL129727NHLBI NIH HHS T32 HL007895NICHD NIH HHS R01 HD069305
6 · The paper itself

Abstract

Four-point electrode systems are commonly used for electric impedance measurements of biomaterials and tissues. We introduce a 2-point system to reduce electrode polarization for heterogeneous measurements of vascular wall. Presence of endoluminal oxidized low density lipoprotein (oxLDL) and lipids alters the electrochemical impedance that can be measured by electrochemical impedance spectroscopy (EIS). We developed a catheter-based 2-point micro-electrode configuration for intravascular deployment in New Zealand White rabbits. An array of 2 flexible round electrodes, 240 µm in diameter and separated by 400 µm was microfabricated and mounted on an inflatable balloon catheter for EIS measurement of the oxLDL-rich lesions developed as a result of high-fat diet-induced hyperlipidemia. Upon balloon inflation, the 2-point electrode array conformed to the arterial wall to allow deep intraplaque penetration via alternating current (AC). The frequency sweep from 10 to 300 kHz generated an increase in capacitance, providing distinct changes in both impedance (Ω) and phase (ϕ) in relation to varying degrees of intraplaque lipid burden in the aorta. Aortic endoluminal EIS measurements were compared with epicardial fat tissue and validated by intravascular ultrasound and immunohistochemistry for plaque lipids and foam cells. Thus, we demonstrate a new approach to quantify endoluminal EIS via a 2-point stretchable electrode strategy.

Indexed as

HyperlipidemiasPlaque, AtheroscleroticAnimalsAortaDielectric SpectroscopyDietary FatsDisease Models, AnimalElectrodesLipoproteins, LDLPericardiumRabbitsDietary FatsLipoproteins, LDLoxidized low density lipoproteinAtherosclerosisElectrochemical impedance spectroscopyFlexible electronicsLipid-rich plaque

Identifiers

PMID26857007
PMCPMC5403741
OpenAlexW2283599955

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.