ArticleSleep2016
Responses in Rat Core Auditory Cortex are Preserved during Sleep Spindle Oscillations.
Article in Sleep, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- Lack of frequency-tagged magnetic responses suggests statistical regularities remain undetected during NREM sleep.Scientific reports · 2018Trial
- Article
- The Geometry of Layer 2/3 Cortical Sound Processing in Slow Wave Sleep.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Modulating sleep: slow oscillation and spindle stimulation effects on physiology and memory.NPJ science of learning · 2026Article
- Heterogeneous synaptic homeostasis: A novel mechanism boosting information propagation in the cortex.PLoS computational biology · 2025Article
- Abrupt and Gradual Changes in Neuronal Processing upon Falling Asleep and Awakening.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neurophysiological effects of targeting sleep spindles with closed-loop auditory stimulation.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Slow and fast cortical cholinergic arousal is reduced in a mouse model of focal seizures with impaired consciousness.Cell reports · 2024Article
- Article
- Oscillatory-Quality of sleep spindles links brain state with sleep regulation and function.Science advances · 2024Article
- Spindle oscillations in communicating axons within a reconstituted hippocampal formation are strongest in CA3 without thalamus.Scientific reports · 2024Article
- Sleep restores an optimal computational regime in cortical networks.Nature neuroscience · 2024Article
- Propofol-mediated Unconsciousness Disrupts Progression of Sensory Signals through the Cortical Hierarchy.Journal of cognitive neuroscience · 2024Article
- Single closed-loop acoustic stimulation targeting memory consolidation suppressed hippocampal ripple and thalamo-cortical spindle activity in mice.The European journal of neuroscience · 2024Article
- Whole-brain analyses indicate the impairment of posterior integration and thalamo-frontotemporal broadcasting in disorders of consciousness.Human brain mapping · 2023Article
- Article
- The Brain Selectively Tunes to Unfamiliar Voices during Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- State-dependent olfactory processing in freely behaving mice.Cell reports · 2022Article
- Tinnitus: at a crossroad between phantom perception and sleep.Brain communications · 2022Review
- Reciprocal relationships between sleep and smell.Frontiers in neural circuits · 2022Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
STUDY
objectivesSleep is defined as a reversible state of reduction in sensory responsiveness and immobility. A long-standing hypothesis suggests that a high arousal threshold during non-rapid eye movement (NREM) sleep is mediated by sleep spindle oscillations, impairing thalamocortical transmission of incoming sensory stimuli. Here we set out to test this idea directly by examining sensory-evoked neuronal spiking activity during natural sleep.
methodsWe compared neuronal (n = 269) and multiunit activity (MUA), as well as local field potentials (LFP) in rat core auditory cortex (A1) during NREM sleep, comparing responses to sounds depending on the presence or absence of sleep spindles.
resultsWe found that sleep spindles robustly modulated the timing of neuronal discharges in A1. However, responses to sounds were nearly identical for all measured signals including isolated neurons, MUA, and LFPs (all differences < 10%). Furthermore, in 10% of trials, auditory stimulation led to an early termination of the sleep spindle oscillation around 150-250 msec following stimulus onset. Finally, active ON states and inactive OFF periods during slow waves in NREM sleep affected the auditory response in opposite ways, depending on stimulus intensity.
conclusionsResponses in core auditory cortex are well preserved regardless of sleep spindles recorded in that area, suggesting that thalamocortical sensory relay remains functional during sleep spindles, and that sensory disconnection in sleep is mediated by other mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.