ArticleEnvironmental science and pollution research international2016
Crocin protects the liver and kidney from patulin-induced apoptosis in vivo.
Article in Environmental science and pollution research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Crocin averts functional and structural rat hepatic disturbances induced by copper oxide nanoparticles.Toxicology research · 2022Article
- Protective role of crocin against sepsis-induced injury in the liver, kidney and lungs via inhibition of p38 MAPK/NF-κB and Bax/Bcl-2 signalling pathways.Pharmaceutical biology · 2022Article
- In vivo and in vitro efficacy of crocin against Echinococcus multilocularis.Parasites & vectors · 2021Article
- Impact of Mycotoxins on Animals' Oxidative Status.Antioxidants (Basel, Switzerland) · 2021Review
- Article
- Protective Effects of Crocin Against Hepatic Damages in D-galactose Aging Model in Rats.Iranian journal of pharmaceutical research : IJPR · 2020Article
- Antifibrotic effects of crocin on thioacetamide-induced liver fibrosis in mice.Saudi journal of biological sciences · 2018Article
- Analysis of the Effect ofJournal of analytical methods in chemistry · 2018Article
- Toxicological effects of patulin mycotoxin on the mammalian system: an overview.Toxicology research · 2017Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patulin (PAT) is a mycotoxin mainly produced by Aspergillus, Penicillium, and Bissochlamys. Given the high risk associated with this mycotoxin, its potential effects have been investigated by many studies. It is known to be teratogenic, mutagenic, and genotoxic, and it has been shown to induce damages in several organs in experimental animals. Our aim was to investigate the preventive effect against PAT-induced apoptosis in vivo using natural carotenoid, Crocin (CRO). Mice were divided into six groups: a control group, a "PAT alone" group, a "CRO alone" group, and a "PAT plus CRO" groups (pre-treatment conditions). Our results showed that CRO restored the normal levels of biochemical parameters in the liver and kidney. The analysis of the protein expression in these organs revealed that PAT-induced toxicity promotes the induction of apoptosis via the increase in P53, Bax, and cytochrome C and the decrease in Bcl2 expressions. We also found that PAT triggered caspase 3 activation and DNA fragmentation. However, pre-treatment with CRO demonstrated a reduction in the induction of apoptosis via the regulation of all tested biomarkers demonstrating that CRO is effective in the protection against PAT hazards. This could be relevant, particularly with the emergent demand for natural products which may counteract the detrimental toxic effects and therefore prevents multiple human diseases.
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