ArticleAntimicrobial agents and chemotherapy2016
Dissecting the Structure-Function Relationship of a Fungicidal Peptide Derived from the Constant Region of Human Immunoglobulins.
Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Anti-Antibiotics (Basel, Switzerland) · 2025Article
- Novel Arginine- and Proline-Rich Candidacidal Peptides Obtained through a Bioinformatic Approach.Antibiotics (Basel, Switzerland) · 2023Article
- Therapeutic Effect of an Antibody-Derived Peptide in aInternational journal of molecular sciences · 2021Article
- In Silico Predicted Antifungal Peptides: In Vitro and In Vivo Anti-Journal of fungi (Basel, Switzerland) · 2021Article
- In Vitro and In Vivo Anti-Journal of fungi (Basel, Switzerland) · 2021Article
- Anti-Infective Antibody-Derived Peptides Active against Endogenous and Exogenous Fungi.Microorganisms · 2021Review
- Discovering a new class of antifungal agents that selectively inhibits microbial carbonic anhydrases.Journal of enzyme inhibition and medicinal chemistry · 2018Article
- Dissection of the Structural Features of a Fungicidal Antibody-Derived Peptide.International journal of molecular sciences · 2018Article
- Novel Activity of a Synthetic Decapeptide AgainstFrontiers in microbiology · 2018Article
- Fungicidal activity of peptides encoded by immunoglobulin genes.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synthetic peptides encompassing sequences related to the complementarity-determining regions of antibodies or derived from their constant region (Fc peptides) were proven to exert differential antimicrobial, antiviral, antitumor, and/or immunomodulatory activitiesin vitroand/orin vivo, regardless of the specificity and isotype of the parental antibody. Alanine substitution derivatives of these peptides exhibited unaltered, increased, or decreased candidacidal activitiesin vitro The bioactive IgG-derived Fc N10K peptide (NQVSLTCLVK) spontaneously self-assembles, a feature previously recognized as relevant for the therapeutic activity of another antibody-derived peptide. We evaluated the contribution of each residue to the peptide self-assembling capability by circular-dichroism spectroscopy. The interaction of the N10K peptide and its derivatives withCandida albicanscells was studied by confocal, transmission, and scanning electron microscopy. The apoptosis and autophagy induction profiles in yeast cells treated with the peptides were evaluated by flow cytometry, and the therapeutic efficacy against candidal infection was studied in aGalleria mellonellamodel. Overall, the results indicate a critical role for some residues in the self-assembly process and a correlation of that capability with the candidacidal activities of the peptidesin vitroand their therapeutic effectsin vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.