Evidence map›Paper›PMID 26856822›Full record

ArticleBiomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals2016

XRF-measured bone lead (Pb) as a biomarker for Pb exposure and toxicity among children diagnosed with Pb poisoning.

Aaron J Specht, Yanfen Lin, Marc Weisskopf, Chonghuai Yan, Howard Hu, Jian Xu, Linda H Nie

Abstract read
In one paragraph

Article in Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
  2. Article
  3. The effect of chelation on bone Pb stores in Pb poisoned children.Journal of exposure science & environmental epidemiology · 2025
    Article
  4. Synthesis of CuInSJournal of fluorescence · 2025
    Article
  5. Measuring historical pollution: Natural history collections as tools for public health and environmental justice research.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Ways to Measure Metals: From ICP-MS to XRF.Current environmental health reports · 2025
    Review
  8. Review
  9. Bone lead measurements of live condors in field to assess cumulative lead exposure.Environmental science and pollution research international · 2024
    Article
  10. Lead exposure across the life course and age at death.The Science of the total environment · 2024
    Article
  11. Article
  12. Article
  13. A State-of-the-Science Review on Metal Biomarkers.Current environmental health reports · 2023
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aaron J Spechta School of Health Sciences , Purdue University , West Lafayette, IN , USA .
Yanfen Linb Xinhua Hospital, MOE-Shanghai Key Laboratory of Children's Environmental Health, Department of Child and Adolescent Healthcare , Shanghai Institute for Pediatric Research, Shanghai Jiao Tong University School of Medicine , Shanghai , China .
Marc Weisskopfc Harvard School of Public Health , Boston, MA , USA , and.
Chonghuai Yanb Xinhua Hospital, MOE-Shanghai Key Laboratory of Children's Environmental Health, Department of Child and Adolescent Healthcare , Shanghai Institute for Pediatric Research, Shanghai Jiao Tong University School of Medicine , Shanghai , China .
Howard Hud Dalla Lana School of Public Health , University of Toronto , Toronto, ON , Canada.
Jian Xub Xinhua Hospital, MOE-Shanghai Key Laboratory of Children's Environmental Health, Department of Child and Adolescent Healthcare , Shanghai Institute for Pediatric Research, Shanghai Jiao Tong University School of Medicine , Shanghai , China .
Linda H Niea School of Health Sciences , Purdue University , West Lafayette, IN , USA .

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
Validation of Portable XRF for In Vivo Measurement of Heavy Metal ExposuresR21ES024700 · NIEHS · RUSH UNIVERSITY MEDICAL CENTER · PI NIE, LINDA H, WEISSKOPF, MARC G · 2015 to 2018
$712k
Development and Validation of a Novel In Vivo Neutron Activation Analysis TechnolR21OH010044 · OH · PURDUE UNIVERSITY · PI NIE, LINDA H · 2012 to 2013
$338k
NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R21 ES024700NIOSH CDC HHS 1R21OH010044NIOSH CDC HHS R21 OH010044
6 · The paper itself

Abstract

Childhood lead (Pb) poisoning remains a global issue, especially in industrial areas. In this study, 115 children with average age 5.7 years were recruited as either patient diagnosed with Pb poisoning or controls at Xinhua Hospital in China. The subjects' bone Pb was measured with a K-shell X-ray fluorescence (KXRF) and a portable X-ray fluorescence (XRF) system. A significant correlation between KXRF bone Pb and blood Pb and portable XRF and KXRF measurements were observed. The half-life of blood-lead was calculated to be 9.96 ± 3.92 d. Our results indicate that bone is a useful biomarker for Pb in children.

Indexed as

Environmental ExposureBiomarkersBone and BonesChildChild, PreschoolChinaHumansLeadLead PoisoningSpectrometry, X-Ray EmissionBiomarkersLeadIn vivoportableX-ray fluorescence

Identifiers

PMID26856822
PMCPMC4964874

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.