ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2016
Influence of durable mechanical circulatory support and allosensitization on mortality after heart transplantation.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Interplay of Pulmonary Hypertension and the Effects of Panel-Reactive Antibodies on Outcomes of Heart Transplant Recipients Bridged With Left Ventricular Assist Device.Journal of the American Heart Association · 2026Article
- Early outcomes in heart transplantation using donation after circulatory death donors in patients bridged with durable left ventricular assist devices.The Journal of thoracic and cardiovascular surgery · 2025Article
- Clinical Outcomes of Cardiac Transplantation in Heart Failure Patients with Previous Mechanical Cardiocirculatory Support.Journal of clinical medicine · 2025Article
- Mechanical circulatory support as a cornerstone in advanced heart failure and transplantation.Frontiers in cardiovascular medicine · 2025Review
- Redefining Cardiac Antibody-Mediated Rejection With Donor-Specific Antibodies and Graft Dysfunction.Circulation. Heart failure · 2024Article
- Review
- Heart transplantation in patients bridged with mechanical circulatory support: outcome comparison with matched controls.ESC heart failure · 2023Article
- Elevated Plasma Immunoglobulin Levels Prior to Heart Transplantation Are Associated with Poor Post-Transplantation Survival.Biology · 2022Article
- Impact of the Pre-Transplant Circulatory Supportive Strategy on Post-Transplant Outcome: Double Bridge May Work.Journal of clinical medicine · 2021Article
- Donor-derived cell-free DNA is associated with cardiac allograft vasculopathy.Clinical transplantation · 2021Article
- A mortality risk score for heart transplants after contemporary ventricular assist device bridging.Journal of cardiac surgery · 2021Article
- Current Desensitization Strategies in Heart Transplantation.Frontiers in immunology · 2021Review
- Pig-to-human heart transplantation: Who goes first?American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020Article
- Consideration of appropriate clinical applications for cardiac xenotransplantation.Clinical transplantation · 2018Article
- Ventricular assist device elicits serum natural IgG that correlates with the development of primary graft dysfunction following heart transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2017Article
- Selection of Patients for Initial Clinical Trials of Solid Organ Xenotransplantation.Transplantation · 2017Review
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7 authors.
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Abstract
backgroundAllosensitization has been shown to negatively affect post-heart transplant (HTx) survival even with a negative crossmatch. Whether allosensitization related to mechanical circulatory support (MCS) is associated with worse post-HTx survival remains controversial.
methodsAdult HTx recipients listed in the United Network for Organ Sharing database (July 2006-December 2012) were identified. Multivariate Cox regression assessed the effect of allosensitization on survival. Propensity matching was performed to compare patients who were and were not allosensitized. Kaplan-Meier survival analysis compared matched and unmatched patients in the MCS and medically managed cohorts.
resultsWe identified 11,840 HTx recipients, of whom 4,167 had MCS. MCS was associated with allosensitization in multivariate logistic regression. Each different MCS device was associated with worse post-HTx survival in multivariate Cox regression. Allosensitization did not predict post-HTx mortality in MCS patients (hazard ratio, 1.07; 95% confidence interval, 0.89-1.28; p = 0.48. Among patients without MCS, allosensitization was associated with post-HTx mortality (hazard ratio, 1.19; 95% confidence interval, 1.03-1.39; p = 0.02). Kaplan-Meier analysis revealed equivalent survival in unmatched and matched cohorts when MCS patients who were allosensitized were compared with non-allosensitized MCS patients. Among non-MCS patients, allosensitization was associated with worse survival in unmatched and matched analysis.
conclusionsMCS was associated with allosensitization. For MCS patients, allosensitization did not independently predict worse post-HTx outcome. Among non-MCS patients, allosensitization was associated with worse post-HTx survival. Allosensitization appears to be a heterogeneous process influenced by presence of MCS.
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