Evidence map›Paper›PMID 26856667›Full record

ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2016

The relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation is modified by donor smoking and reperfusion hyperoxia.

Joshua M Diamond, Mary K Porteous, L Jackson Roberts, Nancy Wickersham, Melanie Rushefski, Steven M Kawut, Rupal J Shah, Edward Cantu, David J Lederer, Shampa Chatterjee and 17 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Risk of primary graft dysfunction following lung transplantation in selected adults with connective tissue disease-associated interstitial lung disease.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021
    Article
  6. Adipose tissue quantification and primary graft dysfunction after lung transplantation: The Lung Transplant Body Composition study.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2019
    Article
  7. Aryl-Hydrocarbon Receptor Repressor Gene in Primary Graft Dysfunction after Lung Transplantation.American journal of respiratory cell and molecular biology · 2019
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 13 institutions in 1 country.

Joshua M DiamondPulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Mary K PorteousPulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
L Jackson RobertsDepartments of Medicine and Pharmacology, Vanderbilt University, Nashville, Tennessee.
Nancy WickershamDivision of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee.
Melanie RushefskiPulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Steven M KawutPulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Rupal J ShahDepartment of Medicine, University of California, San Francisco, California.
Edward CantuDivision of Cardiovascular Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
David J LedererDivision of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, New York.
Shampa ChatterjeeDepartment of Physiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Philadelphia, PA.
Vibha N LamaDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan.
Sangeeta BhoradeDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois.
Maria CrespoDivision of Pulmonary, Allergy, and Critical Care, University of Pittsburgh, Pittsburgh, Pennsylvania.
John McDyerDivision of Pulmonary, Allergy, and Critical Care, University of Pittsburgh, Pittsburgh, Pennsylvania.
Keith WilleDivision of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Jonathan OrensDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Johns Hopkins University Hospital, Baltimore, Maryland.
Ann WeinackerDivision of Pulmonary and Critical Care Medicine, Stanford University, Palo Alto, California.
Selim ArcasoyDivision of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, New York.
Pali D ShahDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Johns Hopkins University Hospital, Baltimore, Maryland.
David S WilkesDivision of Pulmonary, Allergy, Critical Care, and Occupational Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Chadi HageDivision of Pulmonary, Allergy, Critical Care, and Occupational Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Scott M PalmerDivision of Pulmonary, Allergy, and Critical Care Medicine, Duke University, Raleigh-Durham, North Carolina.
Laurie SnyderDivision of Pulmonary, Allergy, and Critical Care Medicine, Duke University, Raleigh-Durham, North Carolina.
Carolyn S CalfeeDepartment of Medicine, University of California, San Francisco, California.
Lorraine B Ware *Departments of Medicine and Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee.
Jason D Christie *Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Lung Transplant Outcomes Group
University of Pennsylvania · USNorthwestern University · USColumbia University · USDuke University · USJohns Hopkins University · USUniversity of California, San Francisco · USUniversity of Pittsburgh · USVanderbilt University · USIndiana University – Purdue University Indianapolis · USIndiana University School of MedicineStanford University · USUniversity of Alabama at Birmingham · USUniversity of Michigan–Ann Arbor · US

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
Clinical Risk Factors for Primary Graft DysfunctionR01HL087115 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHRISTIE, JASON D · 2007 to 2017
$7.1M
Biomarker Profiles in the Diagnosis/Prognosis of ARDSU01HL081332 · NHLBI · VANDERBILT UNIVERSITY · PI WARE, LORRAINE B · 2005 to 2008
$6.0M
Genetics of primary graft dysfunctionR01HL081619 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHRISTIE, JASON D · 2007 to 2011
$3.9M
Obesity, Inflammation, and Lung Injury After Lung TransplantationR01HL114626 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHRISTIE, JASON D, LEDERER, DAVID J. · 2013 to 2016
$3.1M
The GOLD Study: Goal of Open Lung Ventilation in DonorsR01HL126176 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WARE, LORRAINE B · 2015 to 2020
$2.8M
Role of anti-Col (V) immunity in primary graft dysfunctionR01HL096845 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHRISTIE, JASON D, WILKES, DAVID S · 2010 to 2013
$2.2M
Cigarette Smoke Exposure and Acute Lung Injury After Severe Blunt TraumaR01HL110969 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CALFEE, CAROLYN · 2012 to 2016
$1.9M
Midcareer Investigator Award in Patient-Oriented Research in Acute Lung InjuryK24HL103836 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WARE, LORRAINE B · 2010 to 2020
$1.6M
Mentored Patient-Oriented Research in Pulmonary Arterial HypertensionK24HL103844 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAWUT, STEVEN M · 2011 to 2020
$1.6M
Mentored Patient Oriented Research in Lung TransplantationK24HL115354 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHRISTIE, JASON D · 2012 to 2021
$1.2M
Lung Transplant donor: prediction, evaluation, and mechanismK23HL116656 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CANTU, EDWARD · 2013 to 2017
$872k
NHLBI NIH HHS K23 HL116656NHLBI NIH HHS K23 HL121406NHLBI NIH HHS K24 HL103836NHLBI NIH HHS K24 HL103844NHLBI NIH HHS K24 HL115354NHLBI NIH HHS K24HL115354NHLBI NIH HHS R01 HL081619NHLBI NIH HHS R01HL081619NHLBI NIH HHS R01 HL087115NHLBI NIH HHS R01HL087115NHLBI NIH HHS R01 HL096845NHLBI NIH HHS R01HL096845NHLBI NIH HHS R01 HL110969NHLBI NIH HHS R01HL110969NHLBI NIH HHS R01 HL114626NHLBI NIH HHS R01HL114626NHLBI NIH HHS R01 HL126176NHLBI NIH HHS R01HL126176NHLBI NIH HHS R03 HL135227NHLBI NIH HHS U01 HL081332NHLBI NIH HHS U01HL081332NIEHS NIH HHS P30 ES013508
6 · The paper itself

Abstract

backgroundDonor smoking history and higher fraction of inspired oxygen (FIO2) at reperfusion are associated with primary graft dysfunction (PGD) after lung transplantation. We hypothesized that oxidative injury biomarkers would be elevated in PGD, with higher levels associated with donor exposure to cigarette smoke and recipient hyperoxia at reperfusion.

methodsWe performed a nested case-control study of 72 lung transplant recipients from the Lung Transplant Outcomes Group cohort. Using mass spectroscopy, F2-isoprostanes and isofurans were measured in plasma collected after transplantation. Cases were defined in 2 ways: grade 3 PGD present at day 2 or day 3 after reperfusion (severe PGD) or any grade 3 PGD (any PGD).

resultsThere were 31 severe PGD cases with 41 controls and 35 any PGD cases with 37 controls. Plasma F2-isoprostane levels were higher in severe PGD cases compared with controls (28.6 pg/ml vs 19.8 pg/ml, p = 0.03). Plasma F2-isoprostane levels were higher in severe PGD cases compared with controls (29.6 pg/ml vs 19.0 pg/ml, p = 0.03) among patients reperfused with FIO2 >40%. Among recipients of lungs from donors with smoke exposure, plasma F2-isoprostane (38.2 pg/ml vs 22.5 pg/ml, p = 0.046) and isofuran (66.9 pg/ml vs 34.6 pg/ml, p = 0.046) levels were higher in severe PGD compared with control subjects.

conclusionsPlasma levels of lipid peroxidation products are higher in patients with severe PGD, in recipients of lungs from donors with smoke exposure, and in recipients exposed to higher Fio2 at reperfusion. Oxidative injury is an important mechanism of PGD and may be magnified by donor exposure to cigarette smoke and hyperoxia at reperfusion.

Indexed as

Postoperative ComplicationsAdultBiomarkersFemaleFollow-Up StudiesHumansHyperoxiaLipid PeroxidationLung TransplantationMalePrimary Graft DysfunctionReperfusion InjuryRetrospective StudiesSmokingTime FactorsTissue DonorsBiomarkersF2-isoprostaneischemia reperfusionisofuranlipid peroxidationlung transplantationprimary graft dysfunction

Identifiers

PMID26856667
PMCPMC4821817
OpenAlexW2224993362

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.