ArticleScientific reports2016
Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
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- Opening a can of lungworms: Molecular characterization ofInternational journal for parasitology. Parasites and wildlife · 2022Article
- The community-curated Pristionchus pacificus genome facilitates automated gene annotation improvement in related nematodes.BMC genomics · 2021Article
- Speciation and adaptive evolution reshape antioxidant enzymatic system diversity across the phylum Nematoda.BMC biology · 2020Article
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- A Multi-Omics Database for Parasitic Nematodes and Trematodes.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Niche-specific gene expression in a parasitic nematode; increased expression of immunomodulators in Teladorsagia circumcincta larvae derived from host mucosa.Scientific reports · 2017Article
- WormBase ParaSite - a comprehensive resource for helminth genomics.Molecular and biochemical parasitology · 2017Article
- Perusal of parasitic nematode 'omics in the post-genomic era.Molecular and biochemical parasitology · 2017Review
- Genomes of Fasciola hepatica from the Americas Reveal Colonization with Neorickettsia Endobacteria Related to the Agents of Potomac Horse and Human Sennetsu Fevers.PLoS genetics · 2017Article
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Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
Abstract
The bovine lungworm, Dictyocaulus viviparus (order Strongylida), is an important parasite of livestock that causes substantial economic and production losses worldwide. Here we report the draft genome, variome, and developmental transcriptome of D. viviparus. The genome (161 Mb) is smaller than those of related bursate nematodes and encodes fewer proteins (14,171 total). In the first genome-wide assessment of genomic variation in any parasitic nematode, we found a high degree of sequence variability in proteins predicted to be involved host-parasite interactions. Next, we used extensive RNA sequence data to track gene transcription across the life cycle of D. viviparus, and identified genes that might be important in nematode development and parasitism. Finally, we predicted genes that could be vital in host-parasite interactions, genes that could serve as drug targets, and putative RNAi effectors with a view to developing functional genomic tools. This extensive, well-curated dataset should provide a basis for developing new anthelmintics, vaccines, and improved diagnostic tests and serve as a platform for future investigations of drug resistance and epidemiology of the bovine lungworm and related nematodes.
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