ArticleScientific reports2016
Evolutionary functional elaboration of the Elovl2/5 gene family in chordates.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 83 citations in OpenAlex.
- Biosynthesis of long-chain omega-3 fatty acids by the nestlings of a generalist seabird.The Journal of experimental biology · 2025Article
- Effect of Organic Plant Ingredients on the Growth Performance of European Sea Bass (Animals : an open access journal from MDPI · 2025Article
- Molecular Characterization and Nutritional Regulation of Two Fatty Acid Elongase (Biomolecules · 2025Article
- Enzymes enabling the biosynthesis of various COpen biology · 2025Article
- Molecular Identification and Functional Characterization of LC-PUFA Biosynthesis Elongase (Animals : an open access journal from MDPI · 2024Article
- Elongation capacity of polyunsaturated fatty acids in the annelidOpen biology · 2024Article
- Spinocerebellar ataxia 38: structure-function analysis shows ELOVL5 G230V is proteotoxic, conformationally altered and a mutational hotspot.Human genetics · 2023Article
- Determination of dietary essential fatty acids in a deep-sea fish, the splendid alfonsino Beryx splendens: functional characterization of enzymes involved in long-chain polyunsaturated fatty acid biosynthesis.Fish physiology and biochemistry · 2023Article
- A complete inventory of long-chain polyunsaturated fatty acid biosynthesis pathway enzymes in the miniaturized cyprinid Paedocypris micromegethes.Fish physiology and biochemistry · 2022Article
- Effect of Lemna minor supplemented diets on growth, digestive physiology and expression of fatty acids biosynthesis genes of Cyprinus carpio.Scientific reports · 2022Article
- Molecular Characterization, Tissue Distribution and Differential Nutritional Regulation of Three n-3 LC-PUFA Biosynthesis-Related Genes in Hybrid Grouper (Animals : an open access journal from MDPI · 2022Article
- Biosynthesis of Long-Chain Polyunsaturated Fatty Acids in Marine Gammarids: Molecular Cloning and Functional Characterisation of Three Fatty Acyl Elongases.Marine drugs · 2021Article
- Elovl2 But Not Elovl5 Is Essential for the Biosynthesis of Docosahexaenoic Acid (DHA) in Zebrafish: Insight from a Comparative Gene Knockout Study.Marine biotechnology (New York, N.Y.) · 2020Article
- A comparative metabolomics study on anadromous clupeid Tenualosa ilisha for better understanding the influence of habitat on nutritional composition.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Molecular cloning and 3D model of a fatty-acid elongase in a carnivorous freshwater teleost, the European perch (3 Biotech · 2019Article
- Retention of fatty acyl desaturase 1 (fads1) in Elopomorpha and Cyclostomata provides novel insights into the evolution of long-chain polyunsaturated fatty acid biosynthesis in vertebrates.BMC evolutionary biology · 2018Article
- "Genes · 2018Article
- Insights into the phylogenetic and molecular evolutionary histories ofEcology and evolution · 2018Article
- Elongation of very Long-Chain (>CLipids · 2017Article
- Functional characterization and differential nutritional regulation of putative Elovl5 and Elovl4 elongases in large yellow croaker (Larimichthys crocea).Scientific reports · 2017Article
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Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biosynthesis of long-chain polyunsaturated fatty acids (LC-PUFA) provides an intriguing example on how multi-enzymatic cascades evolve. Essential LC-PUFA, such as arachidonic, eicosapentaenoic, and docosahexaenoic acids (DHA), can be acquired from the diet but are also endogenously retailored from C18 precursors through consecutive elongations and desaturations catalyzed, respectively, by fatty acyl elongase and desaturase enzymes. The molecular wiring of this enzymatic pathway defines the ability of a species to biosynthesize LC-PUFA. Exactly when and how in animal evolution a functional LC-PUFA pathway emerged is still elusive. Here we examine key components of the LC-PUFA cascade, the Elovl2/Elovl5 elongases, from amphioxus, an invertebrate chordate, the sea lamprey, a representative of agnathans, and the elephant shark, a basal jawed vertebrate. We show that Elovl2 and Elovl5 emerged from genome duplications in vertebrate ancestry. The single Elovl2/5 from amphioxus efficiently elongates C18 and C20 and, to a marked lesser extent, C22 LC-PUFA. Lamprey is incapable of elongating C22 substrates. The elephant shark Elovl2 showed that the ability to efficiently elongate C22 PUFA and thus to synthesize DHA through the Sprecher pathway, emerged in the jawed vertebrate ancestor. Our findings illustrate how non-integrated "metabolic islands" evolve into fully wired pathways upon duplication and neofunctionalization.
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