Evidence map›Paper›PMID 26856344›Full record

Trial reportThe journal of spinal cord medicine2017

Effect of acute intermittent hypoxia on motor function in individuals with chronic spinal cord injury following ibuprofen pretreatment: A pilot study.

Meaghan Lynch, Lynsey Duffell, Milap Sandhu, Sudarshan Srivatsan, Kelly Deatsch, Allison Kessler, Gordon S Mitchell, Arun Jayaraman, William Zev Rymer

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journal of spinal cord medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.

  1. Acute intermittent hypoxia in spinal cord injury gait rehabilitation: a systematic review of randomized trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Beneficially Stressing the Peripheral Nervous System to Repair.International journal of molecular sciences · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Low level CORespiratory physiology & neurobiology · 2024
    Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Meaghan Lyncha Rehabilitation Institute of Chicago, Northwestern University , Chicago , IL , USA.
Lynsey Duffellb Department of Physical Medicine & Rehabilitation , Northwestern University , Chicago , IL , USA.
Milap Sandhub Department of Physical Medicine & Rehabilitation , Northwestern University , Chicago , IL , USA.
Sudarshan Srivatsana Rehabilitation Institute of Chicago, Northwestern University , Chicago , IL , USA.
Kelly Deatscha Rehabilitation Institute of Chicago, Northwestern University , Chicago , IL , USA.
Allison Kesslera Rehabilitation Institute of Chicago, Northwestern University , Chicago , IL , USA.
Gordon S Mitchelld Department of Physical Therapy and McKnight Brain Institute , University of Florida , Gainesville , FL , USA.
Arun Jayaramanb Department of Physical Medicine & Rehabilitation , Northwestern University , Chicago , IL , USA.
William Zev Rymerh Sensory Motor Performance Program , Rehabilitation Institute of Chicago, Professor, Northwestern University , Chicago , IL , USA.
Northwestern University · USShirley Ryan AbilityLab · USUniversity College London · GBUniversity of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAcute intermittent hypoxia (AIH) enhances lower extremity motor function in humans with chronic incomplete spinal cord injury (SCI). AIH-induced spinal plasticity is inhibited by systemic inflammation in animal models. Since SCI is frequently associated with systemic inflammation in humans, we tested the hypothesis that pretreatment with the anti-inflammatory agent ibuprofen enhances the effects of AIH.

methodsA randomized, double-blinded, placebo-controlled crossover design was used. Nine adults (mean age 51.1 ± 13.1 years) with chronic motor-incomplete SCI (7.7 ± 6.3 years post-injury) received a single dose of ibuprofen (800 mg) or placebo, 90 minutes prior to AIH. For AIH, 9% O

resultsTorque increased significantly after AIH at 30 (P = 0.007; by ∼20%) and 60 (P < 0.001; by ∼30%) minutes post-AIH versus baseline. Ibuprofen did not augment the effects of AIH. EMG activity did not increase significantly after AIH; however, there was a significant association between increases in torque and EMG in both gastrocnemius (R

conclusionsAIH systematically increased lower extremity torque in individuals with chronic incomplete SCI, but there was no significant effect of ibuprofen pretreatment. Our study re-confirms the ability of AIH to enhance leg strength in persons with chronic incomplete SCI.

Indexed as

Isometric ContractionAdultAgedAnalgesics, Non-NarcoticFemaleHumansIbuprofenMaleMiddle AgedOxygenOxygen Inhalation TherapyPilot ProjectsSpinal Cord InjuriesAnalgesics, Non-NarcoticIbuprofenOxygenHumansHypoxiaIbuprofenMuscle strength dynamometerNeuronal plasticityRehabilitationSpinal cord injury

Identifiers

PMID26856344
PMCPMC5472017
OpenAlexW2270060742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.