ArticleEuropean journal of applied physiology2016
The rat closely mimics oxidative stress and inflammation in humans after exercise but not after exercise combined with vitamin C administration.
Article in European journal of applied physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The Impact of H1-H4 Receptor Antagonists on the Levels of Selected Oxidative Stress Markers in Liver and Muscle Tissue in an Animal Model of Colitis.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Investigating the effects of co-exposure to noise and benzene on serum oxidative stress in rat.Toxicology reports · 2024Article
- Critical Velocity, Maximal Lactate Steady State, and Muscle MCT1 and MCT4 after Exhaustive Running in Mice.International journal of molecular sciences · 2023Article
- Exploring the Relationship between Micronutrients and Athletic Performance: A Comprehensive Scientific Systematic Review of the Literature in Sports Medicine.Sports (Basel, Switzerland) · 2023Review
- Nutritional habits and free grazing regimen of productive animals along with specific ingredients are influential factors for the antioxidant properties of milk: From farm to market.Biomedical reports · 2020Article
- Postoperative Administration of Alpha-tocopherol Enhances Osseointegration of Stainless Steel Implants: An In Vivo Rat Model.Clinical orthopaedics and related research · 2020Article
- Benomyl, a benzimidazole fungicide, induces oxidative stress and apoptosis in neural cells.Toxicology reports · 2020Article
- Spectrophotometric assays for measuring redox biomarkers in blood and tissues: the NADPH network.Redox report : communications in free radical research · 2018Review
- Exercise-Induced Oxidative Stress and the Effects of Antioxidant Intake from a Physiological Viewpoint.Antioxidants (Basel, Switzerland) · 2018Review
- Cell‑specific and roasting‑dependent regulation of the Keap1/Nrf2 pathway by coffee extracts.Molecular medicine reports · 2018Article
- Administration of exercise-conditioned plasma alters muscle catalase kinetics in rat: An argument for in vivo-like KRedox biology · 2018Article
- The Janus Head of Oxidative Stress in Metabolic Diseases and During Physical Exercise.Current diabetes reports · 2017Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of the present study was to directly compare oxidative stress and inflammation responses between rats and humans.
methodsWe contrasted rat and human oxidative stress and inflammatory responses to exercise (pro-oxidant stimulus) and/or vitamin C (anti-oxidant stimulus) administration. Vitamin C was administered orally in both species (16 mg kg(-1) of body weight). Twelve redox biomarkers and seven inflammatory biomarkers were determined in plasma and erythrocytes pre- and post-exercise or pre- and post-exercise combined with vitamin C administration.
resultsExercise increased oxidative stress and induced an inflammatory state in rats and humans. There were only 1/19 significant species × exercise interactions (catalase), indicating similar responses to exercise between rats and humans in redox and inflammatory biomarkers. Vitamin C decreased oxidative stress and increased antioxidant capacity only in humans and did not affect the redox state of rats. In contrast, vitamin C induced an anti-inflammatory state only in rats and did not affect the inflammatory state of humans. There were 10/19 significant species × vitamin C interactions, indicating that rats poorly mimic human oxidative stress and inflammatory responses to vitamin C administration. Exercise after acute vitamin C administration altered redox state only in humans and did not affect the redox state of rats. On the contrary, inflammation biomarkers changed similarly after exercise combined with vitamin C in both rats and humans.
conclusionsThe rat adequately mimics human responses to exercise in basic blood redox/inflammatory profile, yet this is not the case after exercise combined with vitamin C administration.
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