ArticleBiointerphases2016
Reduce the matrix effect in biological tissue imaging using dynamic reactive ionization and gas cluster ion beams.
Article in Biointerphases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Pick-Up of Organic Molecules by Mixed Ar Clusters: A Function of Gas Properties and Composition.Molecules (Basel, Switzerland) · 2026Article
- 15-Lipoxygenase-dependent radiomitigation by NORedox biology · 2025Article
- Recent advances in mass spectrometry imaging of single cells.Analytical and bioanalytical chemistry · 2023Review
- Using mass spectrometry imaging to visualize age-related subcellular disruption.Frontiers in molecular biosciences · 2023Review
- ToF-SIMS Depth Profiling of Metal, Metal Oxide, and Alloy Multilayers in Atmospheres of HJournal of the American Society for Mass Spectrometry · 2022Article
- C-O Bond Dissociation and Induced Chemical Ionization Using High Energy (COJournal of the American Society for Mass Spectrometry · 2019Article
- Quantifying SIMS of Organic Mixtures and Depth Profiles-Characterizing Matrix Effects of Fragment Ions.Journal of the American Society for Mass Spectrometry · 2019Article
- Reducing the Matrix Effect in Organic Cluster SIMS Using Dynamic Reactive Ionization.Journal of the American Society for Mass Spectrometry · 2016Article
- CO2 Cluster Ion Beam, an Alternative Projectile for Secondary Ion Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In the context of a secondary ion mass spectrometry (SIMS) experiment, dynamic reactive ionization (DRI) involves introducing a reactive dopant, HCl, into an Ar gas cluster primary ion beam along with a source of water to enable dissociation of HCl to free protons. This concerted effect, precisely occurring at the impact site of the cluster beam, enhances the protonation of molecular species. Here, the authors apply this methodology to study the hippocampus and cerebellum region of a frozen-hydrated mouse brain section. To determine the degree of enhancement associated with DRI conditions, sequential tissue slices were arranged in a mirrored configuration so that comparable regions of the tissue could be explored. The results show that the protonated lipid species are increased by ∼10-fold, but that the normally prevalent salt adducts are virtually unaffected. This observation is discussed as a novel approach to minimizing SIMS matrix effects in complex materials. Moreover, the chemical images of protonated lipid ions exhibit clearer features in the cerebellum region as compared to images acquired with the pure Ar cluster beam.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.