Evidence map›Paper›PMID 26856331›Full record

ArticleVirus genes2016

Immunopotentiation of four natural adjuvants co-administered with a highly pathogenic porcine reproductive and respiratory syndrome virus glycoprotein 5 subunit.

Jun Peng, Yanmei Yuan, Si Shen, Zhongxiang Niu, Yijun Du, Jiaqiang Wu, Jun Li, Jiang Yu, Tao Wang, Jinbao Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Virus genes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jun PengCollege of Veterinary Medicine, Shandong Agricultural University, Taian, China.
Yanmei YuanCollege of Veterinary Medicine, Shandong Agricultural University, Taian, China.
Si ShenCollege of Veterinary Medicine, Shandong Agricultural University, Taian, China.
Zhongxiang NiuCollege of Veterinary Medicine, Shandong Agricultural University, Taian, China.
Yijun DuInstitute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Sangyuan Road No. 10, Jinan, 250100, China.
Jiaqiang WuInstitute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Sangyuan Road No. 10, Jinan, 250100, China.
Jun LiInstitute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Sangyuan Road No. 10, Jinan, 250100, China.
Jiang YuInstitute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Sangyuan Road No. 10, Jinan, 250100, China.
Tao WangCollege of Veterinary Medicine, Shandong Agricultural University, Taian, China.
Jinbao WangCollege of Veterinary Medicine, Shandong Agricultural University, Taian, China. wangjb@saas.ac.cn.
Shandong Agricultural University · CNShandong Academy of Agricultural Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To improve the efficacy of porcine reproductive and respiratory syndrome virus (PRRSV) subunit vaccine, the immunological enhancement effects of four natural adjuvants were compared, including Astragalus extract, Astragalus/Bacillus production, propolis, and Freund's adjuvant. The results showed that titers of IgG and neutralizing antibody against highly pathogenic PRRSV (HP-PRRSV) glycoprotein 5 (GP5) from the groups of Astragalus/Bacillus adjuvant and Freund's adjuvant co-administered with a recombinant HP-PRRSV GP5 subunit were the highest among all the experimental groups. In cellular immunity, as shown in T lymphocyte proliferation level, Astragalus/Bacillus adjuvant and Freund's adjuvant exhibited the most potent immunological enhancement effects. Exceptionally, pigs inoculated with Freund's adjuvant developed severely delayed humoral immune responses within 28 days post inoculation. The adjuvants of Astragalus extract and propolis also exhibited immunological enhancement effects on humoral immune and cell-mediated immune responses, but which were obviously lower than Astragalus/Bacillus adjuvant and Freund's adjuvant. Following challenge with HP-PRRSV, pigs inoculated with Astragalus/Bacillus adjuvant and Freund's adjuvant co-administered with GP5 subunit showed lower viremia, slighter clinical signs, and less pathological lung lesions compared with the groups inoculated using Astragalus extract and propolis. In conclusion, from immune responses and immunological protection against HP-PRRSV, the Astragalus/Bacillus adjuvant demonstrated the most potent immunological enhancement effect on HP-PRRSV GP5 subunit. Astragalus/Bacillus adjuvant showed promise as a candidate immune adjuvant, to more efficiently prevent and control PRRS.

Indexed as

Adjuvants, ImmunologicAnimalsAntibodies, NeutralizingAntibodies, ViralImmunoglobulin GLymphocyte ActivationNeutralization TestsPorcine Reproductive and Respiratory SyndromePorcine respiratory and reproductive syndrome virusRecombinant Fusion ProteinsSwineVaccines, SubunitViral Envelope ProteinsViral LoadAdjuvants, ImmunologicAntibodies, NeutralizingAntibodies, Viralglycoprotein 5, PRRSVImmunoglobulin GRecombinant Fusion ProteinsVaccines, SubunitViral Envelope ProteinsImmunological enhancement effectNatural immune adjuvantPorcine reproductive and respiratory syndrome virus subunit

Identifiers

PMID26856331
OpenAlexW2255265497

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.