Evidence map›Paper›PMID 26856330›Full record

ArticleJournal of translational medicine2016

The long non-coding RNA TUG1 indicates a poor prognosis for colorectal cancer and promotes metastasis by affecting epithelial-mesenchymal transition.

Junfeng Sun, Chaohui Ding, Zhen Yang, Tao Liu, Xiefu Zhang, Chunlin Zhao, Jiaxiang Wang

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 88 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 6 pooled it
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 6 syntheses or guidelines pooled it, 158 citations in OpenAlex.

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  10. Role of Phytoconstituents in Cancer Treatment: A Review.Recent advances in food, nutrition & agriculture · 2024
    Review
  11. H19: An Oncogenic Long Non-coding RNA in Colorectal Cancer.The Yale journal of biology and medicine · 2023
    Review
  12. Interplay of LncRNA TUG1 and TGF-β/P53 Expression in Colorectal Cancer.Asian Pacific journal of cancer prevention : APJCP · 2023
    Article
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Junfeng SunGastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East, Zhengzhou, 450052, China. s_junfeng@163.com.
Chaohui DingGastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East, Zhengzhou, 450052, China. ddchaohui@sina.com.
Zhen YangGastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East, Zhengzhou, 450052, China. 1743288403@qq.com.
Tao LiuGastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East, Zhengzhou, 450052, China. lintao4560@163.com.
Xiefu ZhangGastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East, Zhengzhou, 450052, China. zhuangxfu@sina.com.
Chunlin ZhaoGastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East, Zhengzhou, 450052, China. clin_zhao@163.com.
Jiaxiang WangPediatric Surgery, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East, Zhengzhou, 450052, China. wjiaxw@163.com.
First Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLong intergenic non-coding RNAs (lncRNAs) are a class of non-coding RNAs that are involved in gene expression regulation. Taurine up-regulated gene 1 (TUG1) is a cancer progression related lncRNA in some tumor oncogenesis; however, its role in colorectal cancer (CRC) remains unclear. In this study, we determined the expression patterns of TUG1 in CRC patients and explored its effect on CRC cell metastasis using cultured representative CRC cell lines.

methodsThe expression levels of TUG1 in 120 CRC patients and CRC cells were determined using quantitative real-time PCR. HDACs and epithelial-mesenchymal transition (EMT)-related gene expression were determined using western blot. CRC cell metastasis was assessed by colony formation, migration assay and invasion assay.

resultsOur data showed that the levels of TUG1 were upregulated in both CRC cell lines and primary CRC clinical samples. TUG1 upregulation was closely correlated with the survival time of CRC patients. Overexpression of TUG1 in CRC cells increased their colony formation, migration, and invasion in vitro and promoted their metastatic potential in vivo, whereas knockdown of TUG1 inhibited the colony formation, migration, and invasion of CRC cells in vitro. It is also worth pointing out that TUG1 activated EMT-related gene expression.

conclusionOur data suggest that tumor expression of lncRNA TUG1 plays a critical role in CRC metastasis. TUG1 may have potential roles as a biomarker and/or a therapeutic target in colorectal cancer.

Indexed as

AnimalsCell Line, TumorColorectal NeoplasmsDisease ProgressionEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesGene SilencingHistone DeacetylasesHumansMaleMice, Inbred BALB CMice, NudeMiddle AgedNeoplasm InvasivenessHistone DeacetylasesRNA, Long NoncodingTUG1 long noncoding RNA, human

Identifiers

PMID26856330
PMCPMC4745176
OpenAlexW2268172084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.