ArticleNature communications2016
Genomic insights into the Ixodes scapularis tick vector of Lyme disease.
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Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 279 papers.
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279citing papers in PubMed
59.5field-weighted citation impact, top 1% of its field
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Who cites it
279 citing papers in PubMed, 564 citations in OpenAlex.
- Genome sequencing and multi-stage, blood-feeding, and tissue-specific transcriptome atlas of the Rocky Mountain wood tick provide a critical resource for this vector.Insect biochemistry and molecular biology · 2026Article
- When Clades Collide: Genomic Admixture in Blacklegged Ticks (Ixodes scapularis) From the Great Plains.Molecular ecology · 2026Article
- Identification and Expression Profiling of Scorpion Ionotropic Receptors and Gustatory Receptors Based on the Transcriptomic Analysis.Integrative zoology · 2026Article
- The first chromosome-scale genome assembly for Dermacentor reticulatus: a key vector of tick-borne pathogens of public and veterinary health importance in Europe.BMC biology · 2026Article
- Olfactory gene profiling in ticks: A scoping review with a functional perspective.Veterinary and animal science · 2026Review
- An Nrf2-Nup214 positive feedback loop sustains the antioxidant response and promotes microbial infection in ticks.bioRxiv : the preprint server for biology · 2026Article
- Genome-wide CRISPR knockout cell screening platform for the disease vector tick speciesbioRxiv : the preprint server for biology · 2026Article
- Genome sequencing and multi-stage, blood-feeding, and tissue-specific transcriptome atlas of the Rocky Mountain wood tick provide a critical resource for this vector.bioRxiv : the preprint server for biology · 2026Article
- Molecular bases of insect odorant receptor function: specificity and evolution.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Ticks: Biology, Habitat, Threats and Protection Methods.Biology · 2026Review
- IR25a-like Receptors are Required for Olfactory Detection of Plant Volatiles in the Carmine Spider Mite.Journal of chemical ecology · 2026Article
- Exploring the First Draft Genome of the Oribatid Mite, Oppia nitens: A Standardized Model Invertebrate in Soil Ecotoxicology.Genome biology and evolution · 2026Article
- Chemical Composition Matters! The Role of Nepetalactone Isomers in Tick Repellency.Journal of chemical ecology · 2026Article
- The repetitive genome of the Ixodes ricinus tick reveals transposable elements have driven genome evolution in ticks.Genome biology · 2026Article
- Phase response curve and RNA-sequencing demonstrate spiders' sensitivity to light and pinpoint candidate light-responsive genes.PloS one · 2026Article
- An Integrative Framework Identifies Cooperative Targeting of Host Pathways by Tick Salivary miRNAs.Computational and structural biotechnology journal · 2026Article
- Advances in the use of entomopathogenic fungi to control ixodid ticks.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2026Review
- Copy Number Variation-Based Molecular Sexing ofbioRxiv : the preprint server for biology · 2025Article
- Genome-wide insights into genetic diversity of endemic and non-endemic Ixodes ricinus populations.Scientific reports · 2025Article
- In Silico Analysis of Two Hard Tick P450s: Identification, Characterization, and Putative Metabolism ofInternational journal of molecular sciences · 2025Article
219 more citing papers are in PubMed but not listed here.
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Authors and funding
93 authors at 20 institutions in 9 countries.
Monika Gulia-NussDepartment of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
Andrew B NussDepartment of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
Jason M MeyerDepartment of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
Daniel E SonenshineDepartment of Biological Sciences, Old Dominion University, Norfolk, Virginina 23529, USA.
R Michael RoeDepartment of Entomology, North Carolina State University, Raleigh, North Carolina 27695, USA.
Robert M WaterhouseDepartment of Genetic Medicine and Development, University of Geneva Medical School, Geneva 1211, Switzerland.ORCID http://orcid.org/0000-0003-4199-9052
David B SattelleCentre for Respiratory Biology, UCL Respiratory Department, Division of Medicine, University College London, Rayne Building, 5 University Street, London WC1E 6JF, UK.
José de la FuenteSaBio, Instituto de Investigación en Recursos Cinegéticos, IREC-CSIC-UCLM-JCCM, Ronda de Toledo sn, Ciudad Real 13005, Spain.
Jose M RibeiroLaboratory of Malaria and Vector Research, NIAID, Rockville, Maryland 20852, USA.
Karine MegyVectorBase/EMBL-EBI, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.
Jyothi ThimmapuramBioinformatics Core, Purdue University, West Lafayette, Indiana 47907, USA.
Jason R MillerJ. Craig Venter Institute, Rockville, Maryland 20850, USA.
Brian P WalenzJ. Craig Venter Institute, Rockville, Maryland 20850, USA.
Sergey KorenJ. Craig Venter Institute, Rockville, Maryland 20850, USA.
Jessica B HostetlerJ. Craig Venter Institute, Rockville, Maryland 20850, USA.
Mathangi ThiagarajanJ. Craig Venter Institute, Rockville, Maryland 20850, USA.
Vinita S JoardarJ. Craig Venter Institute, Rockville, Maryland 20850, USA.
Linda I HannickJ. Craig Venter Institute, Rockville, Maryland 20850, USA.
Shelby BidwellJ. Craig Venter Institute, Rockville, Maryland 20850, USA.
Martin P HammondVectorBase/EMBL-EBI, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.
Sarah YoungGenome Sequencing and Analysis Program, Broad Institute, Cambridge, Massachusetts 02142, USA.
Qiandong ZengGenome Sequencing and Analysis Program, Broad Institute, Cambridge, Massachusetts 02142, USA.
Jenica L AbrudanDepartment of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA.
Francisca C AlmeidaDepartament de Genètica &Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Barcelona E-08028, Spain.
Nieves AyllónSaBio, Instituto de Investigación en Recursos Cinegéticos, IREC-CSIC-UCLM-JCCM, Ronda de Toledo sn, Ciudad Real 13005, Spain.
Ketaki BhideBioinformatics Core, Purdue University, West Lafayette, Indiana 47907, USA.
Brooke W BissingerDepartment of Entomology, North Carolina State University, Raleigh, North Carolina 27695, USA.
Elena Bonzon-KulichenkoVascular Physiopathology, Centro Nacional de Investigaciones Cardiovasculares, Madrid 28029, Spain.
Steven D BuckinghamCentre for Respiratory Biology, UCL Respiratory Department, Division of Medicine, University College London, Rayne Building, 5 University Street, London WC1E 6JF, UK.
Daniel R CaffreyDepartment of Medicine, Division of Infectious Diseases, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Melissa J CaimanoDepartment of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA.
Vincent CrosetCenter for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne CH-1015, Switzerland.
Timothy DriscollGenetics, Bioinformatics, and Computational Biology Program, Virginia Bioinformatics Institute at Virginia Tech, Blacksburg, Virginia 24061, USA.
Don GilbertDepartment of Biology, Indiana University, Bloomington, Indiana 47405, USA.ORCID http://orcid.org/0000-0002-6646-7274
Joseph J GillespieGenetics, Bioinformatics, and Computational Biology Program, Virginia Bioinformatics Institute at Virginia Tech, Blacksburg, Virginia 24061, USA.
Gloria I Giraldo-CalderónDepartment of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
Jeffrey M GrabowskiDepartment of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
David JiangDepartment of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, USA.
Sayed M S KhalilDepartment of Microbial Molecular Biology, Agricultural Genetic Engineering Research Institute, Giza 12619, Egypt.
Donghun KimDepartment of Entomology, Texas A&M University, College Station, Texas 77843, USA.
Katherine M KocanDepartment of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, 250 McElroy Hall, Stillwater, Oklahama 74078, USA.
Juraj KočiDepartment of Entomology, Kansas State University, Manhattan, Kansas 66506, USA.
Richard J KuhnDepartment Biological Sciences, Markey Center for Structural Biology, Purdue University, West Lafayette, Indiana 47907, USA.
Timothy J KurttiDepartment of Entomology, University of Minnesota, St Paul, Minnesota 55108, USA.
Kristin LeesDepartment of Neurosystems, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.
Emma G LangDepartment of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
Ryan C KennedyDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94143, USA.
Hyeogsun KwonDepartment of Entomology, Texas A&M University, College Station, Texas 77843, USA.
Rushika PereraDepartment Biological Sciences, Markey Center for Structural Biology, Purdue University, West Lafayette, Indiana 47907, USA.
Yumin QiDepartment of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, USA.
Justin D RadolfDepartment of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA.
Joyce M SakamotoDepartment of Entomology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Alejandro Sánchez-GraciaDepartament de Genètica &Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Barcelona E-08028, Spain.
Maiara S SeveroDepartment of Entomology, Center for Disease Vector Research, University of California, Riverside, California 92506, USA.
Neal SilvermanDepartment of Medicine, Division of Infectious Diseases, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Ladislav ŠimoDepartment of Entomology, Kansas State University, Manhattan, Kansas 66506, USA.
Marta TojoDepartment of Pathology, Cambridge Genomic Services, University of Cambridge, Cambridge CB2 1QP, UK.
Cristian TornadorDepartment of Experimental and Health Sciences, Universidad Pompeu Fabra, Barcelona 08003, Spain.
Janice P Van ZeeDepartment of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
Jesús VázquezVascular Physiopathology, Centro Nacional de Investigaciones Cardiovasculares, Madrid 28029, Spain.
Filipe G VieiraDepartament de Genètica &Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Barcelona E-08028, Spain.
Margarita VillarSaBio, Instituto de Investigación en Recursos Cinegéticos, IREC-CSIC-UCLM-JCCM, Ronda de Toledo sn, Ciudad Real 13005, Spain.
Adam R WespiserDepartment of Medicine, Division of Infectious Diseases, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Yunlong YangDepartment of Entomology, Texas A&M University, College Station, Texas 77843, USA.
Jiwei ZhuDepartment of Entomology, North Carolina State University, Raleigh, North Carolina 27695, USA.
Peter ArensburgerDepartment of Biological Sciences, California State Polytechnic University, Pomona, California 91768, USA.
Patricia V PietrantonioDepartment of Entomology, Texas A&M University, College Station, Texas 77843, USA.
Stephen C BarkerParasitology Section, School of Chemistry &Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.
Renfu ShaoGeneCology Research Centre, Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Maroochydore, Queensland 4556, Australia.
Evgeny M ZdobnovDepartment of Genetic Medicine and Development, University of Geneva Medical School, Geneva 1211, Switzerland.
Frank HauserDepartment of Biology, Center for Functional and Comparative Insect Genomics, University of Copenhagen, Copenhagen DK-2100, Denmark.
Cornelis J P GrimmelikhuijzenDepartment of Biology, Center for Functional and Comparative Insect Genomics, University of Copenhagen, Copenhagen DK-2100, Denmark.
Yoonseong ParkDepartment of Entomology, Kansas State University, Manhattan, Kansas 66506, USA.
Julio RozasDepartament de Genètica &Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Barcelona E-08028, Spain.ORCID http://orcid.org/0000-0002-6839-9148
Richard BentonCenter for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne CH-1015, Switzerland.
Joao H F PedraDepartment of Entomology, Center for Disease Vector Research, University of California, Riverside, California 92506, USA.
David R NelsonDepartment of Microbiology, Immunology &Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.
Maria F UngerDepartment of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA.
Jose M C TubioCancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.
Zhijian TuDepartment of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, USA.
Hugh M RobertsonDepartment of Entomology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Martin ShumwayJ. Craig Venter Institute, Rockville, Maryland 20850, USA.ORCID http://orcid.org/0000-0002-7467-9701
Granger SuttonJ. Craig Venter Institute, Rockville, Maryland 20850, USA.
Jennifer R WortmanJ. Craig Venter Institute, Rockville, Maryland 20850, USA.
Daniel LawsonVectorBase/EMBL-EBI, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.
Stephen K WikelDepartment of Medical Sciences, Frank H. Netter MD School of Medicine at Quinnipiac University, Hamden, Connecticut 06518, USA.
Vishvanath M NeneJ. Craig Venter Institute, Rockville, Maryland 20850, USA.
Claire M FraserInstitute for Genome Sciences, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA.
Frank H CollinsDepartment of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA.
Bruce BirrenThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Karen E NelsonJ. Craig Venter Institute, Rockville, Maryland 20850, USA.
Elisabet CalerJ. Craig Venter Institute, Rockville, Maryland 20850, USA.
Catherine A HillDepartment of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
J. Craig Venter Institute · USPurdue University West Lafayette · USVirginia Tech · USBroad Institute · USEntomological Society of America · USUniversity of Notre Dame · USEuropean Bioinformatics Institute · GBKansas State University · USNorth Carolina State University · USUniversity of Massachusetts Chan Medical School · USInstituto de Investigación en Recursos Cinegéticos · ESOklahoma State University · USSpanish National Centre for Cardiovascular Research · ESUniversitat Autònoma de Barcelona · ESUniversitat de Barcelona · ESUniversity College London · GBUniversity of California, Riverside · USUniversity of Connecticut · USUniversity of Copenhagen · DKUniversity of Lausanne · CH
Funding
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3MVector-Borne Diseases: Biology Of Vector Host RelationshipZIAAI000810 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI RIBEIRO, JOSE · 2009 to 2025
$20.8MSingle-molecule sequence assembly and analysisZIAHG200398 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI PHILLIPPY, ADAM · 2016 to 2025
$15.9MRpoS Regulation of Borrelia burgdorferi Genes in vivoR01AI029735 · NIAID · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI CAIMANO, MELISSA J, RADOLF, JUSTIN D · 1990 to 2022
$10.7MMURINE TYPHUS: VECTOR BIOLOGY AND TRANSMISSIONR01AI017828 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI RAHMAN, MOHAMMED SAYEEDUR · 1985 to 2022
$10.2MFrom Drosophila Immunity to Anti-InflammatoriesR01AI060025 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Neal Silverman · 2004 to 2026
$9.4MINTERSPECIFIC COMPETITION BETWEEN RICKETTSIAE IN TICKSR01AI043006 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI AZAD, ABDU F · 1998 to 2014
$3.3MDevelopment of Celera Whole Genome Shotgun AssemblerR01GM077117 · NIGMS · J. CRAIG VENTER INSTITUTE, INC. · PI MILLER, JASON RAFE · 2006 to 2011
$2.8MSignaling pathways for tick salivary secretionR01AI090062 · NIAID · KANSAS STATE UNIVERSITY · PI PARK, YOONSEONG · 2010 to 2014
$1.5MFirst Transcriptome to the Tick Olfactory SystemR21AI096268 · NIAID · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI ROE, RICHARD MICHAEL · 2011 to 2012
$423kIndiana Clinical and Translational Science Institute-T32 Program TL1TL1TR000162 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI SHEKHAR, ANANTHA · 2012 to 2013
$264kNCATS NIH HHS TL1 TR000162NCATS NIH HHS UL1 TR001108NIAID NIH HHS 1R01AI090062NIAID NIH HHS 1R21AI096268NIAID NIH HHS HHSN266200400001CNIAID NIH HHS HHSN266200400039CNIAID NIH HHS HHSN272200900007CNIAID NIH HHS HHSN272200900039CNIAID NIH HHS HHSN272200900040CNIAID NIH HHS N01 AI030071NIAID NIH HHS N01-AI30071NIAID NIH HHS R01 AI017828NIAID NIH HHS R01AI017828NIAID NIH HHS R01 AI029735NIAID NIH HHS R01 AI043006NIAID NIH HHS R01AI043006NIAID NIH HHS R01 AI060025NIAID NIH HHS R01 AI090062NIAID NIH HHS R21 AI096268NIGMS NIH HHS 5R01GM77117-5NIGMS NIH HHS R01 GM077117
Abstract
Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing ∼57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick-host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host 'questing', prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent.
Indexed as
Anaplasma phagocytophilumAnimalsArachnid VectorsGene Expression ProfilingGenomeGenomicsIxodesLigand-Gated Ion ChannelsLyme DiseaseOocytesXenopus laevisLigand-Gated Ion Channels
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