Evidence map›Paper›PMID 26855759›Full record

ArticleInterface focus2016

Cell and nanoparticle transport in tumour microvasculature: the role of size, shape and surface functionality of nanoparticles.

Ying Li, Yanping Lian, Lucy T Zhang, Saad M Aldousari, Hassan S Hedia, Saeed A Asiri, Wing Kam Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Interface focus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Article
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  4. Nanoparticle-Based Drug Delivery for Vascular Applications.Bioengineering (Basel, Switzerland) · 2024
    Review
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  6. Article
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ying LiDepartment of Mechanical Engineering and Institute of Materials Science , University of Connecticut , Storrs, CT 06269 , USA.ORCID 0000-0002-1487-3350
Yanping LianDepartment of Mechanical Engineering , Northwestern University , Evanston, IL 60201 , USA.
Lucy T ZhangDepartment of Mechanical, Aerospace and Nuclear Engineering , Rensselaer Polytechnic Institute , Troy, NY 12189 , USA.
Saad M AldousariDepartment of Mechanical Engineering , King Abdulaziz University , Jeddah , Saudi Arabia.
Hassan S HediaDepartment of Mechanical Engineering , King Abdulaziz University , Jeddah , Saudi Arabia.
Saeed A AsiriDepartment of Mechanical Engineering , King Abdulaziz University , Jeddah , Saudi Arabia.
Wing Kam LiuDepartment of Mechanical Engineering, Northwestern University, Evanston, IL 60201, USA; Distinguished Scientists Program Committee, King Abdulaziz University, Jeddah, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Through nanomedicine, game-changing methods are emerging to deliver drug molecules directly to diseased areas. One of the most promising of these is the targeted delivery of drugs and imaging agents via drug carrier-based platforms. Such drug delivery systems can now be synthesized from a wide range of different materials, made in a number of different shapes, and coated with an array of different organic molecules, including ligands. If optimized, these systems can enhance the efficacy and specificity of delivery compared with those of non-targeted systems. Emerging integrated multiscale experiments, models and simulations have opened the door for endless medical applications. Current bottlenecks in design of the drug-carrying particles are the lack of knowledge about the dispersion of these particles in the microvasculature and of their subsequent internalization by diseased cells (Bao et al. 2014 J. R. Soc. Interface 11, 20140301 (doi:10.1098/rsif.2014.0301)). We describe multiscale modelling techniques that study how drug carriers disperse within the microvasculature. The immersed molecular finite-element method is adopted to simulate whole blood including blood plasma, red blood cells and nanoparticles. With a novel dissipative particle dynamics method, the beginning stages of receptor-driven endocytosis of nanoparticles can be understood in detail. Using this multiscale modelling method, we elucidate how the size, shape and surface functionality of nanoparticles will affect their dispersion in the microvasculature and subsequent internalization by targeted cells.

Indexed as

drug deliveryfluid–structure interactionmultiscale modelling

Identifiers

PMID26855759
PMCPMC4686248

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.