ArticleInterface focus2016
Continuum theory of fibrous tissue damage mechanics using bond kinetics: application to cartilage tissue engineering.
Article in Interface focus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 44 citations in OpenAlex.
- Theoretical Considerations for Patient-Specific Modeling Based on Observable State Variables.Journal of biomechanical engineering · 2026Article
- Intrinsic Viscoelasticity of Type II Collagen Contributes to the Viscoelastic Response of Immature Bovine Articular Cartilage Under Unconfined Compression Stress Relaxation.Journal of biomechanical engineering · 2026Article
- Investigation of the biodegradation kinetics and associated mechanical properties of 3D-printed polycaprolactone during long-term preclinical testing.Biomaterials · 2025Article
- Modeling Fatigue Failure of Cartilage and Fibrous Biological Tissues Using Constrained Reactive Mixture Theory.Journal of biomechanical engineering · 2024Article
- Continuum Growth Mechanics: Reconciling Two Common Frameworks.Journal of biomechanical engineering · 2024Article
- Modeling fatigue failure in soft tissue using a visco-hyperelastic model with discontinuous damage.Journal of the mechanical behavior of biomedical materials · 2023Article
- Damage Mechanics of Biological Tissues in Relation to Viscoelasticity.Journal of biomechanical engineering · 2023Article
- Finite element modeling of meniscal tears using continuum damage mechanics and digital image correlation.Scientific reports · 2023Article
- Dots-on-Plots: A Web Application to Analyze Stress-Strain Curves From Tensile Tests of Soft Tissue.Journal of biomechanical engineering · 2023Article
- A Numerical Scheme for Anisotropic Reactive Nonlinear Viscoelasticity.Journal of biomechanical engineering · 2023Article
- Development of a continuum damage model to predict accumulation of sub-failure damage in tendons.Journal of the mechanical behavior of biomedical materials · 2022Article
- Continuum Thermodynamics of Constrained Reactive Mixtures.Journal of biomechanical engineering · 2022Article
- On the use of constrained reactive mixtures of solids to model finite deformation isothermal elastoplasticity and elastoplastic damage mechanics.Journal of the mechanics and physics of solids · 2021Article
- Finite Element Implementation of Biphasic-Fluid Structure Interactions in febio.Journal of biomechanical engineering · 2021Article
- A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues.Science advances · 2021Article
- Immature bovine cartilage wear by fatigue failure and delamination.Journal of biomechanics · 2020Article
- A Reactive Inelasticity Theoretical Framework for Modeling Viscoelasticity, Plastic Deformation, and Damage in Fibrous Soft Tissue.Journal of biomechanical engineering · 2019Article
- Finite Element Framework for Computational Fluid Dynamics in FEBio.Journal of biomechanical engineering · 2018Article
- Reactive Constrained Mixtures for Modeling the Solid Matrix of Biological Tissues.Journal Of Elasticity · 2017Article
- An anisotropic multiphysics damage model with application to annulus fibrosus.Journal of biomechanics · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
This study presents a damage mechanics framework that employs observable state variables to describe damage in isotropic or anisotropic fibrous tissues. In this mixture theory framework, damage is tracked by the mass fraction of bonds that have broken. Anisotropic damage is subsumed in the assumption that multiple bond species may coexist in a material, each having its own damage behaviour. This approach recovers the classical damage mechanics formulation for isotropic materials, but does not appeal to a tensorial damage measure for anisotropic materials. In contrast with the classical approach, the use of observable state variables for damage allows direct comparison of model predictions to experimental damage measures, such as biochemical assays or Raman spectroscopy. Investigations of damage in discrete fibre distributions demonstrate that the resilience to damage increases with the number of fibre bundles; idealizing fibrous tissues using continuous fibre distribution models precludes the modelling of damage. This damage framework was used to test and validate the hypothesis that growth of cartilage constructs can lead to damage of the synthesized collagen matrix due to excessive swelling caused by synthesized glycosaminoglycans. Therefore, alternative strategies must be implemented in tissue engineering studies to prevent collagen damage during the growth process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.