ArticleMolecular and cellular biology1989
The Saccharomyces cerevisiae SPT13/GAL11 gene has both positive and negative regulatory roles in transcription.
Article in Molecular and cellular biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed, 100 citations in OpenAlex.
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- Relationships Between RNA Polymerase II Activity and Spt Elongation Factors to Spt- Phenotype and Growth in Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2016Article
- The 9aaTAD Transactivation Domains: From Gal4 to p53.PloS one · 2016Article
- Linking DNA replication to heterochromatin silencing and epigenetic inheritance.Acta biochimica et biophysica Sinica · 2012Review
- Origins and activity of the Mediator complex.Seminars in cell & developmental biology · 2011Review
- Functional conservation of the glutamine-rich domains of yeast Gal11 and human SRC-1 in the transactivation of glucocorticoid receptor Tau 1 in Saccharomyces cerevisiae.Molecular and cellular biology · 2008Article
- A multiplicity of coactivators is required by Gcn4p at individual promoters in vivo.Molecular and cellular biology · 2003Article
- Gal11 is a general activator of basal transcription, whose activity is regulated by the general repressor Sin4 in yeast.Molecular genetics and genomics : MGG · 2003Article
- Restoration of silencing in Saccharomyces cerevisiae by tethering of a novel Sir2-interacting protein, Esc8.Genetics · 2002Article
- The yeast protein Xtc1 functions as a direct transcriptional repressor.Nucleic acids research · 2002Article
- The Swi5 activator recruits the Mediator complex to the HO promoter without RNA polymerase II.Genes & development · 2001Article
- In vivo requirement of activator-specific binding targets of mediator.Molecular and cellular biology · 2000Article
- Sac3, an Snf1-like serine/threonine kinase that positively and negatively regulates the responses of Chlamydomonas to sulfur limitation.The Plant cell · 1999Article
- Article
- Activator-specific requirement of yeast mediator proteins for RNA polymerase II transcriptional activation.Molecular and cellular biology · 1999Article
- Requirement for a functional interaction between mediator components Med6 and Srb4 in RNA polymerase II transcription.Molecular and cellular biology · 1998Article
- Spe3, which encodes spermidine synthase, is required for full repression through NRE(DIT) in Saccharomyces cerevisiae.Genetics · 1998Article
- Molecular genetics of the RNA polymerase II general transcriptional machinery.Microbiology and molecular biology reviews : MMBR · 1998Review
7 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
To understand the function of SPT13, a gene encoding a trans-acting factor involved in regulation of Ty-mediated gene expression, we have cloned and sequenced the gene. Our analysis revealed that SPT13 is the same gene as GAL11, a gene in which mutations cause reduced expression of some GAL4-regulated genes. Further analysis of spt13/gal11 mutants suggested that the SPT13 gene also affects transcription of genes involved in mating-type specialization. We show here that SPT13 has both positive and negative regulatory roles in transcription.
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