ArticleNeuropsychiatric disease and treatment2016
Abnormal resting-state functional connectivity within the default mode network subregions in male patients with obstructive sleep apnea.
Article in Neuropsychiatric disease and treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 4 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 4 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- The contributions of resting-state functional-MRI studies to our understanding of male patients with obstructive sleep apnea: a systematic review.Frontiers in neurology · 2025Pooled it
- Brain Functional and Structural Changes in Alzheimer's Disease With Sleep Disorders: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- A Meta-analysis of Voxel-based Brain Morphometry Studies in Obstructive Sleep Apnea.Scientific reports · 2017Pooled it
- Functional reorganization in obstructive sleep apnoea and insomnia: A systematic review of the resting-state fMRI.Neuroscience and biobehavioral reviews · 2017Pooled it
- Abnormal Intrinsic Functional Hubs in Severe Male Obstructive Sleep Apnea: Evidence from a Voxel-Wise Degree Centrality Analysis.PloS one · 2016Trial
- Sleep-dependent alterations in anterior cingulate cortex excitation-inhibition balance link alterations in BOLD-CSF coupling to cognitive performance in obstructive sleep apnea.Frontiers in aging neuroscience · 2026Article
- Obstructive sleep apnea and structural and functional brain alterations: a brain-wide investigation from clinical association to genetic causality.BMC medicine · 2025Article
- Neurovascular coupling over cortical brain areas and resting state network connectivity with and without rigidified carotid artery.Neurophotonics · 2025Article
- Increased functional connectivity within the salience network in patients with insomnia.Sleep & breathing = Schlaf & Atmung · 2024Article
- Altered functional connectivity of cerebellar subregions in male patients with obstructive sleep apnea: A resting-state fMRI study.Neuroradiology · 2024Article
- Altered Functional Connectivity of Temporoparietal Lobe in Obstructive Sleep Apnea: A Resting-State fNIRS Study.Bioengineering (Basel, Switzerland) · 2024Article
- Functional Connectivity Changes in Amygdala Subregions of Obstructive Sleep Apnea Patients After Six Months of Continuous Positive Airway Pressure Treatment.Nature and science of sleep · 2024Article
- Sleep Deficits Inter-Link Lower Basal Forebrain-Posterior Cingulate Connectivity and Perceived Stress and Anxiety Bidirectionally in Young Men.The international journal of neuropsychopharmacology · 2023Article
- Alteration of functional connectivity despite preserved cerebral oxygenation during acute hypoxia.Scientific reports · 2023Article
- Compensatory mechanisms of reduced interhemispheric EEG connectivity during sleep in patients with apnea.Scientific reports · 2023Article
- Relationship between blood amyloid A and resting magnetic resonance functional brain connections in patients with obstructive sleep apnea-hypopnea syndrome.Sleep & breathing = Schlaf & Atmung · 2023Article
- Altered resting-state functional connectivity patterns in late middle-aged and older adults with obstructive sleep apnea.Frontiers in neurology · 2023Article
- Functional Connectivity Changes in the Insular Subregions of Patients with Obstructive Sleep Apnea after 6 Months of Continuous Positive Airway Pressure Treatment.Neural plasticity · 2023Article
- A Pediatric Patient with Severe Obstructive Sleep Apnea and Comorbid Depression and Substance Abuse.Case reports in psychiatry · 2023Article
- Preliminary study on brain resting-state networks and cognitive impairments of patients with obstructive sleep apnea-hypopnea syndrome.BMC neurology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveAbnormal resting-state functional connectivity (rs-FC) between the central executive network and the default mode network (DMN) in patients with obstructive sleep apnea (OSA) has been reported. However, the effect of OSA on rs-FC within the DMN subregions remains uncertain. This study was designed to investigate whether the rs-FC within the DMN subregions was disrupted and determine its relationship with clinical symptoms in patients with OSA.
methodsForty male patients newly diagnosed with severe OSA and 40 male education- and age-matched good sleepers (GSs) underwent functional magnetic resonance imaging (fMRI) examinations and clinical and neuropsychologic assessments. Seed-based region of interest rs-FC method was used to analyze the connectivity between each pair of subregions within the DMN, including the medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), hippocampus formation (HF), inferior parietal cortices (IPC), and medial temporal lobe (MTL). The abnormal rs-FC strength within the DMN subregions was correlated with clinical and neuropsychologic assessments using Pearson correlation analysis in patients with OSA.
resultsCompared with GSs, patients with OSA had significantly decreased rs-FC between the right HF and the PCC, MPFC, and left MTL. However, patients with OSA had significantly increased rs-FC between the MPFC and left and right IPC, and between the left IPC and right IPC. The rs-FC between the right HF and left MTL was positively correlated with rapid eye movement (r=0.335, P=0.035). The rs-FC between the PCC and right HF was negatively correlated with delayed memory (r=-0.338, P=0.033).
conclusionOSA selectively impairs the rs-FC between right HF and PCC, MPFC, and left MTL within the DMN subregions, and provides an imaging indicator for assessment of cognitive dysfunction in OSA patients.
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