Evidence map›Paper›PMID 26855551›Full record

SynthesisWorld journal of gastroenterology2016

Glutathione S-transferase M1 polymorphism and esophageal cancer risk: An updated meta-analysis based on 37 studies.

Quan-Jun Lu, Ya-Cong Bo, Yan Zhao, Er-Jiang Zhao, Wolde Bekalo Sapa, Ming-Jie Yao, Dan-Dan Duan, Yi-Wei Zhu, Wei-Quan Lu, Ling Yuan

Open access · hybridAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 3 countries.

Quan-Jun LuQuan-Jun Lu, Ya-Cong Bo, Wolde Bekalo Sapa, Dan-Dan Duan, Yi-Wei Zhu, Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan Province, China.
Ya-Cong BoQuan-Jun Lu, Ya-Cong Bo, Wolde Bekalo Sapa, Dan-Dan Duan, Yi-Wei Zhu, Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan Province, China.
Yan ZhaoQuan-Jun Lu, Ya-Cong Bo, Wolde Bekalo Sapa, Dan-Dan Duan, Yi-Wei Zhu, Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan Province, China.
Er-Jiang ZhaoQuan-Jun Lu, Ya-Cong Bo, Wolde Bekalo Sapa, Dan-Dan Duan, Yi-Wei Zhu, Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan Province, China.
Wolde Bekalo SapaQuan-Jun Lu, Ya-Cong Bo, Wolde Bekalo Sapa, Dan-Dan Duan, Yi-Wei Zhu, Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan Province, China.
Ming-Jie YaoQuan-Jun Lu, Ya-Cong Bo, Wolde Bekalo Sapa, Dan-Dan Duan, Yi-Wei Zhu, Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan Province, China.
Dan-Dan DuanQuan-Jun Lu, Ya-Cong Bo, Wolde Bekalo Sapa, Dan-Dan Duan, Yi-Wei Zhu, Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan Province, China.
Yi-Wei ZhuQuan-Jun Lu, Ya-Cong Bo, Wolde Bekalo Sapa, Dan-Dan Duan, Yi-Wei Zhu, Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan Province, China.
Wei-Quan LuQuan-Jun Lu, Ya-Cong Bo, Wolde Bekalo Sapa, Dan-Dan Duan, Yi-Wei Zhu, Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan Province, China.
Ling YuanQuan-Jun Lu, Ya-Cong Bo, Wolde Bekalo Sapa, Dan-Dan Duan, Yi-Wei Zhu, Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan Province, China.
Instituto de Nutricion e Higiene de los Alimentos · CU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the relationship between glutathione S-transferase M1 (GSTM1) polymorphism and susceptibility to esophageal cancer (EC).

methodsA comprehensive search of the United States National Library of Medicine PubMed database and the Elsevier, Springer, and China National Knowledge Infrastructure databases for all relevant studies was conducted using combinations of the following terms: "glutathione S-transferase M1", "GSTM1", "polymorphism", and "EC" (until November 1, 2014). The statistical analysis was performed using the SAS software (v.9.1.3; SAS Institute, Cary, NC, United States) and the Review Manager software (v.5.0; Oxford, England); crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between the GSTM1 null genotype and the risk of EC.

resultsA total of 37 studies involving 2236 EC cases and 3243 controls were included in this meta-analysis. We observed that the GSTM1 null genotype was a significant risk factor for EC in most populations (OR = 1.33, 95%CI: 1.12-1.57, P heterogeneity < 0.000001, and I (2) = 77.0%), particularly in the Asian population (OR = 1.53, 95%CI: 1.26-1.86, P heterogeneity < 0.000001, and I (2) = 77.0%), but not in the Caucasian population (OR = 1.02, 95%CI: 0.87-1.19, P heterogeneity = 0.97, and I (2) = 0%).

conclusionThe GSTM1 null polymorphism may be associated with an increased risk for EC in Asian but not Caucasian populations.

Indexed as

Polymorphism, GeneticAsian PeopleCase-Control StudiesChi-Square DistributionEsophageal NeoplasmsGenetic Association StudiesGenetic Predisposition to DiseaseGlutathione TransferaseHumansOdds RatioPhenotypeRisk AssessmentRisk FactorsGlutathione TransferaseDeletionsEsophageal cancerGlutathione S-transferase M1Meta-analysisPolymorphism

Identifiers

PMID26855551
PMCPMC4724623
OpenAlexW2419048865

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.